Timers, variability, and body-wide coordination: C. elegans as a model system for whole-animal developmental timing

IF 3.7 2区 生物学 Q2 CELL BIOLOGY
Gouri Patil, Jeroen S van Zon
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引用次数: 0

Abstract

Successful development requires both precise timing of cellular processes, such as division and differentiation, and tight coordination of timing between tissues and organs. Yet, how time information is encoded with high precision and synchronized between tissues, despite inherent molecular noise, is unsolved. Here, we propose the nematode C. elegans as a unique model system for studying body-wide control of developmental timing. Recent studies combining genetics, quantitative analysis, and simulations have 1) mapped core timers controlling larval development, indicating temporal gradients as an underlying mechanism, and 2) elucidated general principles that make timing insensitive to inherent fluctuations and variation in environmental conditions. As the molecular regulators of C. elegans developmental timing are broadly conserved, these mechanisms likely apply also to higher organisms.

定时器、可变性和全身协调:作为整个动物发育定时模型系统的眼镜蛇
成功的发育既需要细胞过程(如分裂和分化)的精确时间,也需要组织和器官之间时间的紧密协调。然而,尽管存在固有的分子噪音,时间信息是如何高精度编码并在组织间同步的,这个问题仍未解决。在此,我们建议将线虫作为研究全身发育时间控制的独特模式系统。最近的研究结合了遗传学、定量分析和模拟,1)绘制了控制幼虫发育的核心定时器,表明时间梯度是其基本机制;2)阐明了使定时对环境条件的固有波动和变化不敏感的一般原理。由于秀丽隐杆线虫发育定时的分子调控因子具有广泛的保守性,这些机制很可能也适用于高等生物。
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来源期刊
CiteScore
7.90
自引率
0.00%
发文量
102
审稿时长
1 months
期刊介绍: Current Opinion in Genetics and Development aims to stimulate scientifically grounded, interdisciplinary, multi-scale debate and exchange of ideas. It contains polished, concise and timely reviews and opinions, with particular emphasis on those articles published in the past two years. In addition to describing recent trends, the authors are encouraged to give their subjective opinion of the topics discussed. In Current Opinion in Genetics and Development we help the reader by providing in a systematic manner: 1. The views of experts on current advances in their field in a clear and readable form. 2. Evaluations of the most interesting papers, annotated by experts, from the great wealth of original publications.[...] The subject of Genetics and Development is divided into six themed sections, each of which is reviewed once a year: • Cancer Genomics • Genome Architecture and Expression • Molecular and genetic basis of disease • Developmental mechanisms, patterning and evolution • Cell reprogramming, regeneration and repair • Genetics of Human Origin / Evolutionary genetics (alternate years)
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