Sex differences in the context dependency of episodic memory

IF 2.6 3区 医学 Q2 BEHAVIORAL SCIENCES
Aliza A. Le, Linda C. Palmer, Jasmine Chavez, Christine M. Gall, Gary Lynch
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引用次数: 0

Abstract

Context contributes to multiple aspects of human episodic memory including segmentation and retrieval. The present studies tested if, in adult male and female mice, context influences the encoding of odors encountered in a single unsupervised sampling session of the type used for the routine acquisition of episodic memories. The three paradigms used differed in complexity (single vs. multiple odor cues) and period from sampling to testing. Results show that males consistently encode odors in a context-dependent manner: the mice discriminated novel from previously sampled cues when tested in the chamber of initial cue sampling but not in a distinct yet familiar chamber. This was independent of the interval between cue encounters or the latency from initial sampling to testing. In contrast, female mice acquired both single cues and the elements of multi-cue episodes, but recall of that information was dependent upon the surrounding context only when the cues were presented serially. These results extend the list of episodic memory features expressed by rodents and also introduce a striking and unexpected sex difference in context effects.

外显记忆语境依赖性的性别差异
情境有助于人类外显记忆的多个方面,包括分割和检索。本研究测试了在成年雄性和雌性小鼠中,情境是否会影响它们对在单次无监督采样过程中遇到的气味进行编码,这种采样过程是用于日常获得外显记忆的。所使用的三种范式在复杂性(单一气味线索与多种气味线索)和从取样到测试的时间上都有所不同。结果表明,雄性小鼠始终以一种依赖于情境的方式对气味进行编码:当小鼠在最初的线索采样室中进行测试时,能分辨出新颖的和以前采样过的线索,而在另一个不同但熟悉的室中进行测试时则不能。这与遇到线索的间隔时间或从最初取样到测试的延迟时间无关。相反,雌性小鼠既能获得单一线索,也能获得多线索事件的要素,但只有当线索连续出现时,对这些信息的回忆才取决于周围的情境。这些结果扩展了啮齿类动物所表达的情节记忆特征列表,并在情境效应方面引入了一个显著的、出乎意料的性别差异。
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来源期刊
Frontiers in Behavioral Neuroscience
Frontiers in Behavioral Neuroscience BEHAVIORAL SCIENCES-NEUROSCIENCES
CiteScore
4.70
自引率
3.30%
发文量
506
审稿时长
6-12 weeks
期刊介绍: Frontiers in Behavioral Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the neural mechanisms underlying behavior. Field Chief Editor Nuno Sousa at the Instituto de Pesquisa em Ciências da Vida e da Saúde (ICVS) is supported by an outstanding Editorial Board of international experts. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. This journal publishes major insights into the neural mechanisms of animal and human behavior, and welcomes articles studying the interplay between behavior and its neurobiological basis at all levels: from molecular biology and genetics, to morphological, biochemical, neurochemical, electrophysiological, neuroendocrine, pharmacological, and neuroimaging studies.
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