Ecological distribution, heavy metals profiling and human health risk assessment of medicinal plants used for tonsillitis and wounds treatment: A chemometric approach

Q2 Environmental Science

Environmental Advances Pub Date : 2024-02-22 DOI:10.1016/j.envadv.2024.100503

Zemene Abebe , Seada Mohammed , Andualem Ejigu , Tsegu Lijalem , Atnafu Guadie , Mengistu Mulu , Tamene Beshaw , Walelign Wubet , Getinet Masresha , Molla Tefera

{"title":"Ecological distribution, heavy metals profiling and human health risk assessment of medicinal plants used for tonsillitis and wounds treatment: A chemometric approach","authors":"Zemene Abebe , Seada Mohammed , Andualem Ejigu , Tsegu Lijalem , Atnafu Guadie , Mengistu Mulu , Tamene Beshaw , Walelign Wubet , Getinet Masresha , Molla Tefera","doi":"10.1016/j.envadv.2024.100503","DOIUrl":null,"url":null,"abstract":"<div>Medicinal plants in Ethiopia are easily accessible, relatively low cost and trusted by the community, which drives people to use them to treat a variety of ailments for many years. For instance, Kalanchoe petition, Rhamnus prinoide & Acmella caulirhiza are the most popular medicinal plants that have been used for treating tonsillitis, while Brucea antidysenteric, Justicia shimperian, Jatropha curcas & Prunus Africana have been used for treating wounds. However, the presence of toxic chemicals like heavy metals above threshold concentrations poses a global threat to human health. This study was conducted to determine the levels of heavy metals and to evaluate non-carcinogenic and carcinogenic health impacts posed by using medicinal plants so as to create awareness among users about the chemical compositions of these plants. Five hundred grams of leaves, barks and flowers of the medicinal plants were collected randomly from ten plants from Ayehu Guwagusa and Asagirt districts, Amhara Regional State, Ethiopia in July 2022, and 0.5 g of homogenized samples were digested with HNO3 and HClO4 and the levels of metals were determined using Flame Atomic Absorption Spectroscopy (FAAS). The levels were (mg/kg) Fe: 173.6 ± 9.1-332.2 ± 9.2, Zn: 8.7 ± 0.2-40.2 ± 0.3, Cu: 29 ± 4- 84.1 ± 4.7, Mn: 17.03 ± 1.6- 77.4 ± 1.7, Ni: BDL- 41.4 ± 4.3, and Pb: 21.3 ± 15.1- 49.9 ± 9.6. Cd was found to below the detection limit. The hazard index is less than unity, ranged from 6.64 × 10−4 (J. schimperiana) to 6.43 × 10−3 (J. curcas) for all samples, indicating no significant non-carcinogenic effect on users due to heavy metals. Similarly, the carcinogenic risk values of Ni were raged from 6.64 × 10−9 in B. antidysenterica to 1.16 × 10−8 in J. curcas and for Pb it was found to be 6.04 × 10−8 in R. prinoides and 1.41 × 10−7 in J. curcas.Therefore, the results of this study indicated that the exposed populations are unlikely to experience any adverse cancer risk.</div>","PeriodicalId":34473,"journal":{"name":"Environmental Advances","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666765724000218/pdfft?md5=e7a64ae1c2364ed01c583e72d1273ca1&pid=1-s2.0-S2666765724000218-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environmental Advances","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2666765724000218","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Environmental Science","Score":null,"Total":0}

引用次数: 0

Abstract

Medicinal plants in Ethiopia are easily accessible, relatively low cost and trusted by the community, which drives people to use them to treat a variety of ailments for many years. For instance, Kalanchoe petition, Rhamnus prinoide & Acmella caulirhiza are the most popular medicinal plants that have been used for treating tonsillitis, while Brucea antidysenteric, Justicia shimperian, Jatropha curcas & Prunus Africana have been used for treating wounds. However, the presence of toxic chemicals like heavy metals above threshold concentrations poses a global threat to human health. This study was conducted to determine the levels of heavy metals and to evaluate non-carcinogenic and carcinogenic health impacts posed by using medicinal plants so as to create awareness among users about the chemical compositions of these plants. Five hundred grams of leaves, barks and flowers of the medicinal plants were collected randomly from ten plants from Ayehu Guwagusa and Asagirt districts, Amhara Regional State, Ethiopia in July 2022, and 0.5 g of homogenized samples were digested with HNO₃ and HClO₄ and the levels of metals were determined using Flame Atomic Absorption Spectroscopy (FAAS). The levels were (mg/kg) Fe: 173.6 ± 9.1-332.2 ± 9.2, Zn: 8.7 ± 0.2-40.2 ± 0.3, Cu: 29 ± 4- 84.1 ± 4.7, Mn: 17.03 ± 1.6- 77.4 ± 1.7, Ni: BDL- 41.4 ± 4.3, and Pb: 21.3 ± 15.1- 49.9 ± 9.6. Cd was found to below the detection limit. The hazard index is less than unity, ranged from 6.64 × 10⁻⁴ (J. schimperiana) to 6.43 × 10⁻³ (J. curcas) for all samples, indicating no significant non-carcinogenic effect on users due to heavy metals. Similarly, the carcinogenic risk values of Ni were raged from 6.64 × 10⁻⁹ in B. antidysenterica to 1.16 × 10⁻⁸ in J. curcas and for Pb it was found to be 6.04 × 10⁻⁸ in R. prinoides and 1.41 × 10⁻⁷ in J. curcas.

Therefore, the results of this study indicated that the exposed populations are unlikely to experience any adverse cancer risk.

查看原文本刊更多论文

用于扁桃体炎和伤口治疗的药用植物的生态分布、重金属分析和人类健康风险评估：化学计量学方法

埃塞俄比亚的药用植物很容易获得，价格相对较低，而且深受社区居民的信赖，这促使人们多年来一直使用这些植物治疗各种疾病。例如，Kalanchoe petition、Rhamnus prinoide & Acmella caulirhiza 是治疗扁桃体炎最常用的药用植物，而 Brucea antidysenteric、Justicia shimperian、Jatropha curcas & Prunus Africana 则被用于治疗伤口。然而，重金属等有毒化学物质的存在超过了阈值浓度，对人类健康构成了全球性威胁。本研究旨在确定重金属的含量，并评估使用药用植物对健康造成的非致癌和致癌影响，从而提高使用者对这些植物化学成分的认识。2022 年 7 月，在埃塞俄比亚阿姆哈拉地区州 Ayehu Guwagusa 和 Asagirt 县随机采集了 10 种药用植物的叶片、树皮和花，共 500 克，用 HNO3 和 HClO4 对 0.5 克均质样品进行消化，并使用火焰原子吸收光谱（FAAS）测定了其中的金属含量。其含量分别为（毫克/千克）：铁：173.6 ± 9.1-332.2 ± 9.2；锌：8.7 ± 0.2-40.2 ± 0.3；铜：29 ± 4- 84.1 ± 4.7；锰：17.03 ± 1.6- 8.2 ± 0.3；锌：8.7 ± 0.2-40.2 ± 0.3；铜：29 ± 4- 84.1 ± 4.7：17.03 ± 1.6- 77.4 ± 1.7，镍：BDL- 41.4 ± 4.3，铅：21.3 ± 15.1- 49.9 ± 9.6。镉的含量低于检测限。所有样本的危害指数均小于 1，范围为 6.64 × 10-4（J. schimperiana）至 6.43 × 10-3（J. curcas），表明重金属对使用者没有明显的非致癌影响。同样，镍的致癌风险值从 B. antidysenterica 的 6.64 × 10-9 到 J. curcas 的 1.16 × 10-8，铅的致癌风险值从 R. prinoides 的 6.04 × 10-8 到 J. curcas 的 1.41 × 10-7。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Environmental Advances Environmental Science-Environmental Science (miscellaneous)

CiteScore

7.30

自引率

0.00%

发文量

165

审稿时长

12 weeks