Luis Jesuino de Oliveira Andrade, Luís Matos de Oliveira, Alcina Maria Vinhaes Bittencourt, Letícia Góes de Carvalho Lourenço, Gabriela Correia Matos de Oliveira
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引用次数: 0
Abstract
The disability of cells to react to insulin, causing glucose intolerance and hyperglycemia, is referred to as insulin resistance. This clinical condition, which has been well-researched in organs such as adipose tissue, muscle, and liver, has been linked to neurodegenerative diseases like Alzheimer's disease (AD) when it occurs in the brain.
Objective: The authors aimed to gather data from the current literature on brain insulin resistance (BIR) and its likely repercussions on neurodegenerative disorders, more specifically AD, through a systematic review.
Methods: A comprehensive search was conducted in multiple medical databases, including the Cochrane Central Register of Controlled Trials, EMBASE, Medical Literature Analysis and Retrieval System Online (Medline), and PubMed®, employing the descriptors: "insulin resistance", "brain insulin resistance", "Alzheimer's disease", "neurodegeneration", and "cognition". The authors focused their search on English-language studies published between 2000 and 2023 that investigated the influence of BIR on neurodegenerative disorders or offered insights into BIR's underlying mechanisms. Seventeen studies that met the inclusion criteria were selected.
Results: The results indicate that BIR is a phenomenon observed in a variety of neurodegenerative disorders, including AD. Studies suggest that impaired glucose utilization and uptake, reduced adenosine triphosphate (ATP) production, and synaptic plasticity changes caused by BIR are linked to cognitive problems. However, conflicting results were observed regarding the association between AD and BIR, with some studies suggesting no association.
Conclusion: Based on the evaluated studies, it can be concluded that the association between AD and BIR remains inconclusive, and additional research is needed to elucidate this relationship.
细胞无法对胰岛素做出反应，导致葡萄糖不耐受和高血糖，被称为胰岛素抵抗。这种临床症状在脂肪组织、肌肉和肝脏等器官中已得到充分研究，而当它发生在大脑时，则与阿尔茨海默病（AD）等神经退行性疾病有关：作者旨在通过系统性综述从现有文献中收集有关脑胰岛素抵抗（BIR）及其对神经退行性疾病（尤其是阿尔茨海默病）可能产生的影响的数据：在多个医学数据库中进行了全面检索，包括 Cochrane Central Register of Controlled Trials、EMBASE、Medline Medical Literature Analysis and Retrieval System Online（医学文献分析与检索系统）和 PubMed®，检索时使用了以下描述符："胰岛素抵抗"、"脑胰岛素抵抗"、"阿尔茨海默病"、"神经变性 "和 "认知"。作者重点检索了 2000 年至 2023 年间发表的、研究脑胰岛素抵抗对神经退行性疾病的影响或揭示脑胰岛素抵抗内在机制的英文研究。研究结果表明，BIR是一种神经退行性疾病：结果表明，BIR 是包括 AD 在内的多种神经退行性疾病中观察到的一种现象。研究表明，BIR 导致的葡萄糖利用和摄取受损、三磷酸腺苷（ATP）生成减少以及突触可塑性变化与认知问题有关。然而，关于注意力缺失症与 BIR 之间的关联，研究结果相互矛盾，有些研究表明两者之间没有关联：根据所评估的研究，可以得出结论：AD 与 BIR 之间的关系仍无定论，需要进行更多的研究来阐明这种关系。
期刊介绍：
Dementia top Neuropsychologia the official scientific journal of the Cognitive Neurology and Ageing Department of the Brazilian Academy of Neurology and of the Brazilian Association of Geriatric Neuropsychiatry, is published by the "Associação Neurologia Cognitiva e do Comportamento", a nonprofit Brazilian association. Regularly published on March, June, September, and December since 2007.
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