Evaluation of methods measuring medication adherence in patients with polypharmacy: a longitudinal and patient perspective.

IF 2.4 3区医学 Q3 PHARMACOLOGY & PHARMACY

European Journal of Clinical Pharmacology Pub Date : 2024-06-01 Epub Date: 2024-03-01 DOI:10.1007/s00228-024-03661-1

Laura Mortelmans, Eva Goossens, Marjan De Graef, Jana Van Dingenen, Anne-Marie De Cock, Mirko Petrovic, Patricia van den Bemt, Tinne Dilles

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引用次数: 0

Abstract

Purpose: To explore patients' willingness to have medication adherence measured using different methods and evaluate the feasibility and validity of their combination (i.e., pill counts, a medication diary and a questionnaire assessing adherence two months post-discharge).

Methods: (1) A cross-sectional evaluation of the willingness of patients with polypharmacy to have their medication adherence measured post-discharge. (2) Medication adherence was monitored during two months using pill counts based on preserved medication packages and a diary in which patients registered their adherence-related problems. During a home visit, the Probabilistic Medication Adherence Scale (ProMAS) and a questionnaire on feasibility were administered.

Results: A total of 144 participants completed the questionnaire at discharge. The majority was willing to communicate truthfully about their adherence (97%) and to share adherence-related information with healthcare providers (99%). More participants were willing to preserve medication packages (76%) than to complete a medication diary (67%) during two months. Most participants reported that preserving medication packages (91%), completing the diary (99%) and the ProMAS (99%) were no effort to them. According to the majority of participants (60%), pill counts most accurately reflected medication adherence, followed by the diary (39%) and ProMAS (1%). Medication adherence measured by pill counts correlated significantly with ProMAS scores, but not with the number of diary-reported problems. However, adherence measured by the medication diary and ProMAS correlated significantly.

Conclusion: Combining tools for measuring adherence seems feasible and can provide insight into the accordance of patients' actual medication use with their prescribed regimen, but also into problems contributing to non-adherence.

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多药合用患者用药依从性测量方法评估：纵向和患者视角。

目的：探讨患者使用不同方法（即药片计数、用药日记和出院后两个月的用药依从性评估问卷）进行用药依从性测量的意愿，并评估其组合的可行性和有效性。方法：（1）对使用多种药物的患者出院后进行用药依从性测量的意愿进行横断面评估。(2)在两个月的时间里，根据保存的药物包装进行药片计数，并通过日记记录患者在用药过程中遇到的相关问题，从而对患者的用药依从性进行监测。在家访期间，进行了用药依从性概率量表（ProMAS）和可行性问卷调查：共有 144 名参与者在出院时完成了问卷调查。大多数参与者愿意如实告知自己的用药依从性（97%），并愿意与医疗服务提供者分享与用药依从性相关的信息（99%）。在两个月内，愿意保留药物包装（76%）的参与者多于愿意填写用药日记（67%）的参与者。大多数参与者表示，保存药包（91%）、完成用药日记（99%）和 ProMAS（99%）对他们来说并不费力。大多数参与者（60%）认为，药片计数能最准确地反映服药依从性，其次是日记（39%）和 ProMAS（1%）。通过药片计数衡量的服药依从性与 ProMAS 分数有显著相关性，但与日记中报告的问题数量没有相关性。然而，通过用药日记和ProMAS测量的用药依从性有明显的相关性：结论：结合多种工具来测量依从性似乎是可行的，不仅可以了解患者实际用药与处方用药的一致性，还可以了解导致不依从的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Clinical Pharmacology 医学-药学

CiteScore

5.40

自引率

3.40%

发文量

170

审稿时长

3-8 weeks

期刊介绍： The European Journal of Clinical Pharmacology publishes original papers on all aspects of clinical pharmacology and drug therapy in humans. Manuscripts are welcomed on the following topics: therapeutic trials, pharmacokinetics/pharmacodynamics, pharmacogenetics, drug metabolism, adverse drug reactions, drug interactions, all aspects of drug development, development relating to teaching in clinical pharmacology, pharmacoepidemiology, and matters relating to the rational prescribing and safe use of drugs. Methodological contributions relevant to these topics are also welcomed. Data from animal experiments are accepted only in the context of original data in man reported in the same paper. EJCP will only consider manuscripts describing the frequency of allelic variants in different populations if this information is linked to functional data or new interesting variants. Highly relevant differences in frequency with a major impact in drug therapy for the respective population may be submitted as a letter to the editor. Straightforward phase I pharmacokinetic or pharmacodynamic studies as parts of new drug development will only be considered for publication if the paper involves -a compound that is interesting and new in some basic or fundamental way, or -methods that are original in some basic sense, or -a highly unexpected outcome, or -conclusions that are scientifically novel in some basic or fundamental sense.