Shaping the future of precision oncology: Integrating circadian medicine and mathematical models for personalized cancer treatment

IF 3.4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Janina Hesse , Nina Nelson , Angela Relógio
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引用次数: 0

Abstract

The growing numbers of cancer cases represent a medical and societal burden worldwide. More than half of all cancer patients are treated with chemotherapy. Yet, chemotherapeutic drugs kill not only cancer cells, but also healthy tissue, causing massive adverse side effects. Recent research on circadian medicine suggests that side-effects can be reduced, and treatment efficacy increased, by considering the biological clock of patients. Integrating circadian profiles of molecular clock markers in personalized mathematical models can simulate individual circadian dynamics of drug uptake, drug action and cellular response to chemotherapy. This requires advanced computational tools that balance prediction quality with overfitting. Personalized mathematical models will eventually lead to an optimal alignment of treatment timing with the inner circadian clock of the patient, reducing side effects, increasing efficacy and enhancing patient well-being.

Abstract Image

塑造精准肿瘤学的未来:整合昼夜节律医学和数学模型,实现个性化癌症治疗
癌症病例的不断增加给全世界带来了医疗和社会负担。一半以上的癌症患者接受化疗。然而,化疗药物不仅会杀死癌细胞,也会杀死健康组织,从而产生大量不良副作用。最新的昼夜节律医学研究表明,考虑患者的生物钟可以减少副作用,提高治疗效果。在个性化数学模型中整合分子时钟标记的昼夜节律特征,可以模拟药物吸收、药物作用和细胞对化疗反应的个体昼夜节律动态。这需要先进的计算工具在预测质量与过度拟合之间取得平衡。个性化数学模型最终将使治疗时间与病人的内在昼夜节律时钟达到最佳协调,从而减少副作用、提高疗效并改善病人的健康状况。
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来源期刊
Current Opinion in Systems Biology
Current Opinion in Systems Biology Mathematics-Applied Mathematics
CiteScore
7.10
自引率
2.70%
发文量
20
期刊介绍: Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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