Novel Ti surface coated with PVA hydrogel and chitosan nanoparticles with antibacterial drug release: An experimental in vitro study

IF 3.7 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Implant Dentistry and Related Research Pub Date : 2024-02-28 DOI:10.1111/cid.13305

Pablo Yael Carrazco Ávila, Teresa Arias Moliz, Juan Ignacio Rosales Leal, Pilar Baca, Miguel Ángel Rodríguez Valverde, María Encarnación Morales Hernandez

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引用次数: 0

Abstract

Objectives

The aims of this study were to design a novel titanium surface coated with a PVA hydrogel matrix and chitosan-based nanoparticles and to investigate the antibiotic release and its ability to inhibit microbial activity.

Methods

Two drug delivery systems were developed and mixed. Chitosan-based nanoparticles (NP) and a polyvinyl alcohol film (PVA). The size, ζ-potential, stability, adhesive properties, and encapsulation profile of NP, as well as the release kinetics of drug delivery systems and their antimicrobial ability of PVA and PVANP films, were studied on Ti surfaces. The systems were loaded with doxycycline, vancomycin, and doxepin hydrochloride.

Results

Nanoparticles presented a ζ-potential greater than 30 mV for 45 days and the efficiency drug encapsulation was 26.88% ± 1.51% for doxycycline, 16.09% ± 10.24% for vancomycin and 17.57% ± 11.08% for doxepin. In addition, PVA films were loaded with 125 μg/mL of doxycycline, 125 μg/mL of vancomycin, and 100 μg/mL of doxepin. PVANP-doxycycline achieved the antibacterial effect at 4 h while PVA-doxycycline maintained its effect at 24 h.

Abstract Image

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新型钛表面涂覆 PVA 水凝胶和壳聚糖纳米颗粒并释放抗菌药物：体外实验研究。

研究目的本研究的目的是设计一种新型钛表面涂覆 PVA 水凝胶基质和壳聚糖基纳米颗粒，并研究抗生素的释放及其抑制微生物活性的能力：开发并混合了两种给药系统。甲壳素纳米颗粒（NP）和聚乙烯醇薄膜（PVA）。在 Ti 表面研究了 NP 的尺寸、ζ电位、稳定性、粘附性和包封概况，以及 PVA 和 PVANP 薄膜的给药系统释放动力学和抗菌能力。结果表明：纳米颗粒在钛表面上的释放动力学与 PVA 和 PVANP 薄膜的抗菌能力相当：结果：纳米颗粒在 45 天内的ζ电位大于 30 mV，多西环素的药物封装效率为 26.88% ± 1.51%，万古霉素为 16.09% ± 10.24%，多塞平为 17.57% ± 11.08%。此外，PVA 薄膜还负载了 125 μg/mL 多西环素、125 μg/mL 万古霉素和 100 μg/mL 多塞平。PVANP-多西环素在 4 小时内达到抗菌效果，而 PVA-多西环素在 24 小时内保持效果。

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来源期刊

Clinical Implant Dentistry and Related Research 医学-牙科与口腔外科

CiteScore

6.00

自引率

13.90%

发文量

103

审稿时长

4-8 weeks

期刊介绍： The goal of Clinical Implant Dentistry and Related Research is to advance the scientific and technical aspects relating to dental implants and related scientific subjects. Dissemination of new and evolving information related to dental implants and the related science is the primary goal of our journal. The range of topics covered by the journals will include but be not limited to: New scientific developments relating to bone Implant surfaces and their relationship to the surrounding tissues Computer aided implant designs Computer aided prosthetic designs Immediate implant loading Immediate implant placement Materials relating to bone induction and conduction New surgical methods relating to implant placement New materials and methods relating to implant restorations Methods for determining implant stability A primary focus of the journal is publication of evidenced based articles evaluating to new dental implants, techniques and multicenter studies evaluating these treatments. In addition basic science research relating to wound healing and osseointegration will be an important focus for the journal.