An ingestible self-propelling device for intestinal reanimation

IF 26.1 1区计算机科学 Q1 ROBOTICS

Science Robotics Pub Date : 2024-02-28 DOI:10.1126/scirobotics.adh8170

Shriya S. Srinivasan, Julien Dosso, Hen-Wei Huang, George Selsing, Amro Alshareef, Johannes Kuosmanen, Keiko Ishida, Joshua Jenkins, Wiam Abdalla Mohammed Madani, Alison Hayward, Giovanni Traverso

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Abstract

Postoperative ileus (POI) is the leading cause of prolonged hospital stay after abdominal surgery and is characterized by a functional paralysis of the digestive tract, leading to symptoms such as constipation, vomiting, and functional obstruction. Current treatments are mainly supportive and inefficacious and yield acute side effects. Although electrical stimulation studies have demonstrated encouraging pacing and entraining of the intestinal slow waves, no devices exist today to enable targeted intestinal reanimation. Here, we developed an ingestible self-propelling device for intestinal reanimation (INSPIRE) capable of restoring peristalsis through luminal electrical stimulation. Optimizing mechanical, material, and electrical design parameters, we validated optimal deployment, intestinal electrical luminal contact, self-propelling capability, safety, and degradation of the device in ex vivo and in vivo swine models. We compared the INSPIRE’s effect on motility in models of normal and depressed motility and chemically induced ileus. Intestinal contraction improved by 44% in anesthetized animals and up to 140% in chemically induced ileus cases. In addition, passage time decreased from, on average, 8.6 days in controls to 2.5 days with the INSPIRE device, demonstrating significant improvement in motility. Luminal electrical stimulation of the intestine via the INSPIRE efficaciously restored peristaltic activity. This noninvasive option offers a promising solution for the treatment of ileus and other motility disorders.

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用于肠道复生的可食用自推进装置。

术后回肠梗阻（POI）是腹部手术后住院时间延长的主要原因，其特点是消化道功能性麻痹，导致便秘、呕吐和功能性梗阻等症状。目前的治疗方法主要是支持性的，效果不佳，而且会产生急性副作用。尽管电刺激研究表明，肠道慢波的起搏和诱导效果令人鼓舞，但目前还没有任何设备可以实现有针对性的肠道复苏。在这里，我们开发了一种用于肠道复生的可吞咽自推进装置（INSPIRE），能够通过管腔电刺激恢复肠道蠕动。通过优化机械、材料和电气设计参数，我们在体内外猪模型中验证了该装置的最佳部署、肠腔电接触、自推进能力、安全性和降解性。我们比较了 INSPIRE 在运动正常、运动减弱和化学诱导回肠模型中对运动的影响。麻醉动物的肠道收缩能力提高了 44%，而化学诱导回肠病例的肠道收缩能力则提高了 140%。此外，使用 INSPIRE 设备后，通过时间从对照组的平均 8.6 天缩短到 2.5 天，这表明肠道运动得到了显著改善。通过 INSPIRE 对肠道进行腔隙电刺激可有效恢复肠道蠕动。这种无创疗法为治疗回肠和其他运动障碍提供了一种前景广阔的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science Robotics Mathematics-Control and Optimization

CiteScore

30.60

自引率

2.80%

发文量

期刊介绍： Science Robotics publishes original, peer-reviewed, science- or engineering-based research articles that advance the field of robotics. The journal also features editor-commissioned Reviews. An international team of academic editors holds Science Robotics articles to the same high-quality standard that is the hallmark of the Science family of journals. Sub-topics include: actuators, advanced materials, artificial Intelligence, autonomous vehicles, bio-inspired design, exoskeletons, fabrication, field robotics, human-robot interaction, humanoids, industrial robotics, kinematics, machine learning, material science, medical technology, motion planning and control, micro- and nano-robotics, multi-robot control, sensors, service robotics, social and ethical issues, soft robotics, and space, planetary and undersea exploration.