Biosynthesis and function of 7-deazaguanine derivatives in bacteria and phages.

IF 8 1区生物学 Q1 MICROBIOLOGY

Microbiology and Molecular Biology Reviews Pub Date : 2024-03-27 Epub Date: 2024-02-29 DOI:10.1128/mmbr.00199-23

Valérie de Crécy-Lagard, Geoffrey Hutinet, José D D Cediel-Becerra, Yifeng Yuan, Rémi Zallot, Marc G Chevrette, R M Madhushi N Ratnayake, Marshall Jaroch, Samia Quaiyum, Steven Bruner

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引用次数: 0

Abstract

SUMMARYDeazaguanine modifications play multifaceted roles in the molecular biology of DNA and tRNA, shaping diverse yet essential biological processes, including the nuanced fine-tuning of translation efficiency and the intricate modulation of codon-anticodon interactions. Beyond their roles in translation, deazaguanine modifications contribute to cellular stress resistance, self-nonself discrimination mechanisms, and host evasion defenses, directly modulating the adaptability of living organisms. Deazaguanine moieties extend beyond nucleic acid modifications, manifesting in the structural diversity of biologically active natural products. Their roles in fundamental cellular processes and their presence in biologically active natural products underscore their versatility and pivotal contributions to the intricate web of molecular interactions within living organisms. Here, we discuss the current understanding of the biosynthesis and multifaceted functions of deazaguanines, shedding light on their diverse and dynamic roles in the molecular landscape of life.

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细菌和噬菌体中 7-脱氮鸟嘌呤衍生物的生物合成和功能。

摘要脱氮鸟嘌呤修饰在 DNA 和 tRNA 的分子生物学中发挥着多方面的作用，塑造了多种多样但又必不可少的生物过程，包括翻译效率的微妙微调和密码子-反密码子相互作用的复杂调节。除了在翻译中的作用外，脱氮鸟嘌呤修饰还有助于细胞的抗压性、自我与非自我辨别机制和宿主逃避防御机制，直接调节生物体的适应性。脱氮鸟嘌呤分子的作用不仅限于核酸修饰，还体现在具有生物活性的天然产物的结构多样性上。它们在基本细胞过程中的作用以及在具有生物活性的天然产物中的存在凸显了它们的多功能性以及对生物体内错综复杂的分子相互作用网络的关键贡献。在这里，我们将讨论目前对脱氮鸟嘌呤的生物合成和多方面功能的理解，揭示它们在生命分子景观中的多样化动态作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbiology and Molecular Biology Reviews 生物-微生物学

CiteScore

18.80

自引率

0.80%

发文量

期刊介绍： Microbiology and Molecular Biology Reviews (MMBR), a journal that explores the significance and interrelationships of recent discoveries in various microbiology fields, publishes review articles that help both specialists and nonspecialists understand and apply the latest findings in their own research. MMBR covers a wide range of topics in microbiology, including microbial ecology, evolution, parasitology, biotechnology, and immunology. The journal caters to scientists with diverse interests in all areas of microbial science and encompasses viruses, bacteria, archaea, fungi, unicellular eukaryotes, and microbial parasites. MMBR primarily publishes authoritative and critical reviews that push the boundaries of knowledge, appealing to both specialists and generalists. The journal often includes descriptive figures and tables to enhance understanding. Indexed/Abstracted in various databases such as Agricola, BIOSIS Previews, CAB Abstracts, Cambridge Scientific Abstracts, Chemical Abstracts Service, Current Contents- Life Sciences, EMBASE, Food Science and Technology Abstracts, Illustrata, MEDLINE, Science Citation Index Expanded (Web of Science), Summon, and Scopus, among others.