Increased Extracellular Water in Normal-Appearing White Matter in Patients with Cerebral Small Vessel Disease.

IF 2.5 4区医学 Q3 NEUROSCIENCES

Journal of integrative neuroscience Pub Date : 2024-02-22 DOI:10.31083/j.jin2302046

Shuqian Man, Songkuan Chen, Zhihua Xu, Hongxia Zhang, Zhenyu Cao

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引用次数: 0

Abstract

Background: Microcirculatory variations have been observed in the normal-appearing white matter (NAWM) of individuals affected by cerebral small vessel disease (CSVD). These variations collectively possess the potential to trigger neuroinflammation and edema, ultimately leading to an elevation in extracellular fluid (ECF). Nevertheless, the specific alterations in ECF within the NAWM of CSVD patients have remained inadequately understood.

Methods: We reviewed the clinical and imaging characteristics of a cohort comprising 129 patients diagnosed with CSVD to investigate alterations in the ECF within NAWM. The severity of CSVD was assessed by total CSVD magnetic resonance (MR) score according to the four imaging markers, namely perivascular space, lacunar infarction, white matter hyperintensities and cerebral microbleed. ECF was evaluated by the parameter free water (FW), ranging from 0 to 1 generated from diffusion tensor imaging.

Results: Significant differences in NAWM FW were observed in relation to the total CSVD MR score (p < 0.05). Patients with a total CSVD MR score of 0 exhibited significantly lower NAWM free water (FW) values compared to those with a score greater than 0 (p < 0.05). Similarly, patients with a total CSVD MR score of 1 also demonstrated notably lower NAWM FW values than those with a score greater than 1 (p < 0.05). After conducting multivariate regression analysis, age and total CSVD MR score was independently associated with FW in NAWM (p < 0.001). Further, the total CSVD MR score served as a partial mediator in the relationship between age and FW in the NAWM among patients with CSVD.

Conclusions: ECF in NAWM is increased in CSVD patients, even during the early course of CSVD.

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大脑小血管疾病患者正常表象白质中的细胞外水分增加

背景：在受脑小血管疾病（CSVD）影响的正常外观白质（NAWM）中观察到了微循环变化。这些变化有可能共同引发神经炎症和水肿，最终导致细胞外液（ECF）的增加。然而，人们对 CSVD 患者 NAWM 中 ECF 的具体变化仍缺乏足够的了解：我们回顾了由 129 名确诊为 CSVD 患者组成的队列的临床和成像特征，以研究 NAWM 内 ECF 的变化。CSVD的严重程度通过CSVD磁共振（MR）总分进行评估，该总分根据四种成像标志物确定，即血管周围间隙、腔隙性梗死、白质高密度和脑微出血。ECF由扩散张量成像生成的自由水（FW）参数进行评估，范围从0到1：结果：NAWM FW 与 CSVD MR 总分存在显著差异（P < 0.05）。CSVD MR 总分为 0 的患者的 NAWM 自由水（FW）值明显低于总分大于 0 的患者（p < 0.05）。同样，CSVD MR 总分为 1 分的患者的 NAWM 自由水值也明显低于总分大于 1 分的患者（P < 0.05）。在进行多变量回归分析后，年龄和 CSVD MR 总分与 NAWM 的 FW 值独立相关（p < 0.001）。此外，在 CSVD 患者中，CSVD MR 总分是年龄与 NAWM FW 关系的部分中介因素：结论：即使在 CSVD 的早期病程中，CSVD 患者 NAWM 中的 ECF 也会增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of integrative neuroscience 医学-神经科学

CiteScore

2.80

自引率

5.60%

发文量

173

审稿时长

2 months

期刊介绍： JIN is an international peer-reviewed, open access journal. JIN publishes leading-edge research at the interface of theoretical and experimental neuroscience, focusing across hierarchical levels of brain organization to better understand how diverse functions are integrated. We encourage submissions from scientists of all specialties that relate to brain functioning.