Thick silk fibroin vascular graft: A promising tissue-engineered scaffold material for abdominal vein grafts in middle-sized mammals.

IF 1.4 4区 医学 Q4 ENGINEERING, BIOMEDICAL
Kaito Fukuda, Junichi Kaneko, Sho Kiritani, Yui Sawa, Masaaki Morito, Mariko Tanaka, Tetsuo Ushiku, Chieh-Jen Cheng, Takashi Tanaka, Ryo Tanaka, Tetsuo Asakura, Yoshikuni Kawaguchi, Nobuhisa Akamatsu, Kiyoshi Hasegawa
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引用次数: 0

Abstract

Abdominal vein replacement with synthetic tissue-engineered vascular grafts constructed from silk-based scaffold material has not been reported in middle-sized mammals. Fourteen canines that underwent caudal vena cava replacement with a silk fibroin (SF) vascular graft (15 mm long and 8 mm diameter) prepared with natural silk biocompatible thread were allocated to two groups, thin and thick SF groups, based on the graft wall thickness. The short-term patency rate and histologic reactions were compared. The patency rate at 2 weeks after replacement in the thin and thick SF groups was 50% and 88%, respectively (p = 0.04). CD31-positive endothelial cells covered the luminal surface of both groups at 4 weeks. The elastic modulus of the thick SF graft was significantly better than that of the thin SF graft (0.0210 and 0.0007 N/m2, p < 0.01). Roundness of thick SF groups (o = 0.8 mm) was better than thin SF (o = 2.0 mm). There was significant difference between the groups (p = 0.01). SF vascular grafts are a promising tissue-engineered scaffold material for abdominal venous system replacement in middle-sized mammals, with thick-walled grafts being superior to thin-walled grafts.

厚丝纤维素血管移植物:一种用于中等体型哺乳动物腹部静脉移植的前景看好的组织工程支架材料。
在中等体型的哺乳动物中,尚未见过用蚕丝基支架材料制成的合成组织工程血管移植物置换腹腔静脉的报道。14只犬接受了用天然丝生物相容性线制备的丝纤维蛋白(SF)血管移植物(长15毫米,直径8毫米)置换尾腔静脉的手术,根据移植物壁的厚度将它们分为两组,即薄SF组和厚SF组。比较了短期通畅率和组织学反应。薄SF组和厚SF组置换后2周的通畅率分别为50%和88%(P = 0.04)。4 周时,CD31 阳性的内皮细胞覆盖了两组的管腔表面。厚 SF 移植的弹性模量(0.0210 和 0.0007 N/m2,p o = 0.8 mm)明显优于薄 SF(o = 2.0 mm)。组间差异明显(p = 0.01)。SF血管移植物是一种很有前景的组织工程支架材料,可用于中型哺乳动物的腹腔静脉系统置换,厚壁移植物优于薄壁移植物。
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来源期刊
International Journal of Artificial Organs
International Journal of Artificial Organs 医学-工程:生物医学
CiteScore
3.40
自引率
5.90%
发文量
92
审稿时长
3 months
期刊介绍: The International Journal of Artificial Organs (IJAO) publishes peer-reviewed research and clinical, experimental and theoretical, contributions to the field of artificial, bioartificial and tissue-engineered organs. The mission of the IJAO is to foster the development and optimization of artificial, bioartificial and tissue-engineered organs, for implantation or use in procedures, to treat functional deficits of all human tissues and organs.
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