Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options.

IF 19 1区 医学 Q1 MICROBIOLOGY
Clinical Microbiology Reviews Pub Date : 2024-06-13 Epub Date: 2024-02-29 DOI:10.1128/cmr.00135-23
Stefano Di Bella, Gianfranco Sanson, Jacopo Monticelli, Verena Zerbato, Luigi Principe, Mauro Giuffrè, Giuseppe Pipitone, Roberto Luzzati
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引用次数: 0

Abstract

SUMMARYClostridioides difficile infection (CDI) is one of the major issues in nosocomial infections. This bacterium is constantly evolving and poses complex challenges for clinicians, often encountered in real-life scenarios. In the face of CDI, we are increasingly equipped with new therapeutic strategies, such as monoclonal antibodies and live biotherapeutic products, which need to be thoroughly understood to fully harness their benefits. Moreover, interesting options are currently under study for the future, including bacteriophages, vaccines, and antibiotic inhibitors. Surveillance and prevention strategies continue to play a pivotal role in limiting the spread of the infection. In this review, we aim to provide the reader with a comprehensive overview of epidemiological aspects, predisposing factors, clinical manifestations, diagnostic tools, and current and future prophylactic and therapeutic options for C. difficile infection.

艰难梭菌感染:历史、流行病学、风险因素、预防、临床表现、治疗和未来选择。
摘要 艰难梭状芽孢杆菌感染(CDI)是医院内感染的主要问题之一。这种细菌不断演变,给临床医生带来了复杂的挑战,在现实生活中经常会遇到。面对 CDI,我们越来越多地采用了新的治疗策略,如单克隆抗体和活体生物治疗产品。此外,目前正在研究未来的有趣方案,包括噬菌体、疫苗和抗生素抑制剂。监测和预防策略在限制感染传播方面仍起着关键作用。在这篇综述中,我们旨在向读者全面介绍艰难梭菌感染的流行病学、易感性因素、临床表现、诊断工具以及当前和未来的预防和治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clinical Microbiology Reviews
Clinical Microbiology Reviews 医学-微生物学
CiteScore
54.20
自引率
0.50%
发文量
38
期刊介绍: Clinical Microbiology Reviews (CMR) is a journal that primarily focuses on clinical microbiology and immunology.It aims to provide readers with up-to-date information on the latest developments in these fields.CMR also presents the current state of knowledge in clinical microbiology and immunology.Additionally, the journal offers balanced and thought-provoking perspectives on controversial issues in these areas.
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