{"title":"Therapeutic Potential of Stem Cells in Natural Killer-Like B Cell-Associated Diseases.","authors":"Manali Rupareliya, Pravin Shende","doi":"10.1007/5584_2024_799","DOIUrl":null,"url":null,"abstract":"<p><p>Stem cells are undifferentiated cells possessing a remarkable capacity to develop into multiple cell types. NKB cells, referred to \"natural killer-like B cells,\" are recently identified subtype of B lymphocytes possessing characteristics that are similar to both natural killer (NK) cells and regular B lymphocytes. NK cells are lymphocyte-like in structure and cytotoxic in nature participating in the immediate immune response to the infected or malignant cells, whereas B lymphocytes produce antibodies and participate in adaptive immune response by binding to the specific antigen. The identification of NKB cells brings up new possibilities for studying and perhaps modulating immune responses in a variety of diseases, particularly those associated with microbial infections or inflammatory responses. Further, correlation of NKB cells with interleukins allows us to understand the molecular mechanism of diseases. Stem cell research offers a better understanding of NKB cell participation and provides new insights for novel treatment methods wherein mesenchymal stem cells (MSCs) have found to be the most promising stem cell showing positive outcomes in NKB cell-associated inflammatory diseases. Additionally, the perceptions acquired from researching NKB cells in diverse diseases leads to innovative treatment options, improving our capacity to control and cure immunological dysregulation-related ailments.</p>","PeriodicalId":7270,"journal":{"name":"Advances in experimental medicine and biology","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advances in experimental medicine and biology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/5584_2024_799","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}
引用次数: 0
Abstract
Stem cells are undifferentiated cells possessing a remarkable capacity to develop into multiple cell types. NKB cells, referred to "natural killer-like B cells," are recently identified subtype of B lymphocytes possessing characteristics that are similar to both natural killer (NK) cells and regular B lymphocytes. NK cells are lymphocyte-like in structure and cytotoxic in nature participating in the immediate immune response to the infected or malignant cells, whereas B lymphocytes produce antibodies and participate in adaptive immune response by binding to the specific antigen. The identification of NKB cells brings up new possibilities for studying and perhaps modulating immune responses in a variety of diseases, particularly those associated with microbial infections or inflammatory responses. Further, correlation of NKB cells with interleukins allows us to understand the molecular mechanism of diseases. Stem cell research offers a better understanding of NKB cell participation and provides new insights for novel treatment methods wherein mesenchymal stem cells (MSCs) have found to be the most promising stem cell showing positive outcomes in NKB cell-associated inflammatory diseases. Additionally, the perceptions acquired from researching NKB cells in diverse diseases leads to innovative treatment options, improving our capacity to control and cure immunological dysregulation-related ailments.
干细胞是一种未分化细胞,具有发育成多种细胞类型的非凡能力。NKB 细胞,即 "类自然杀伤 B 细胞",是最近发现的 B 淋巴细胞亚型,具有与自然杀伤(NK)细胞和普通 B 淋巴细胞相似的特征。NK 细胞结构类似淋巴细胞,具有细胞毒性,参与对感染或恶性细胞的直接免疫反应,而 B 淋巴细胞则产生抗体,通过与特定抗原结合参与适应性免疫反应。NKB 细胞的鉴定为研究和调节各种疾病的免疫反应,尤其是与微生物感染或炎症反应相关的疾病带来了新的可能性。此外,NKB 细胞与白细胞介素的相关性使我们能够了解疾病的分子机制。干细胞研究让我们对 NKB 细胞的参与有了更好的了解,并为新型治疗方法提供了新的见解,其中间充质干细胞(MSCs)被认为是最有前途的干细胞,对 NKB 细胞相关炎症疾病有积极的疗效。此外,通过研究 NKB 细胞在各种疾病中的作用,我们还获得了创新治疗方案,提高了控制和治疗免疫调节失调相关疾病的能力。
期刊介绍:
Advances in Experimental Medicine and Biology provides a platform for scientific contributions in the main disciplines of the biomedicine and the life sciences. This series publishes thematic volumes on contemporary research in the areas of microbiology, immunology, neurosciences, biochemistry, biomedical engineering, genetics, physiology, and cancer research. Covering emerging topics and techniques in basic and clinical science, it brings together clinicians and researchers from various fields.