Determination of Perfluorinated Substances (PFAS) Using LC-ORBITRAP-MS in Certain foodstuffs of Animal Origin According to newly established EU legislation

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Analytical Methods Pub Date : 2024-02-28 DOI:10.1007/s12161-024-02603-y

Elina Pasecnaja, Dzintars Zacs

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引用次数: 0

Abstract

Per- and polyfluorinated alkyl substances (PFASs) are compounds which exhibit unique chemical and physical properties resulting in bioaccumulation in aquatic and terrestrial food chains. Due to a global concern on the adverse health effects, European Food Safety Authority (EFSA) set tolerable weekly intake and thereafter, to ensure an efficient protection of public health, the European Commission set maximum levels for four priority components, namely perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorohexanesulfonic acid (PFHxS), and perfluorooctanesulfonic acid (PFOS), in certain foodstuffs. This study demonstrates an analytical method based on high-performance liquid chromatography (HPLC) coupled to Orbitrap mass spectrometry (Orbitrap-MS) for the quantitative determination of four priority PFASs. The optimized and validated LC-Orbitrap-MS method fulfils the requirements specified in the “Guidance Document on Analytical Parameters for the Determination of Per- and Polyfluoroalkyl Substances (PFASs) in Food and Feed” and allows a reliable analysis of PFASs in selected food products, fulfilling the requirements of Commission Regulation 915/2023, Commission Regulation (EU) 2022/1428, and Commission Recommendation (EU) 2022/1431. The method was successfully used for the compliance testing of four priority PFASs according to the newly established legislation in food samples (n = 58) represented by eggs, fish, meat, and meat by-products collected in Latvia, providing the occurrence data from the Baltic states.

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根据新制定的欧盟法规，使用 LC-ORBITRAP-MS 检测某些动物源性食品中的全氟物质 (PFAS)

全氟和多氟烷基物质（PFASs）是一种化合物，具有独特的化学和物理特性，可在水生和陆生食物链中进行生物累积。由于全球都在关注全氟烷基化合物对健康的不良影响，欧洲食品安全局（EFSA）设定了每周可容忍摄入量，随后，为确保有效保护公众健康，欧盟委员会设定了某些食品中四种优先成分的最高含量，即全氟辛酸（PFOA）、全氟壬酸（PFNA）、全氟己烷磺酸（PFHxS）和全氟辛烷磺酸（PFOS）。本研究展示了一种基于高效液相色谱法（HPLC）和 Orbitrap 质谱法（Orbitrap-MS）的分析方法，用于定量检测四种重点 PFASs。经过优化和验证的 LC-Orbitrap-MS 方法符合《食品和饲料中全氟化合物和多氟烷基物质 (PFASs) 检测分析参数指导文件》中规定的要求，可对特定食品中的 PFASs 进行可靠分析，满足欧盟委员会第 915/2023 号条例、欧盟委员会第 2022/1428 号条例和欧盟委员会第 2022/1431 号建议书的要求。该方法被成功用于拉脱维亚收集的鸡蛋、鱼、肉和肉类副产品等食品样品（n = 58）中四种优先考虑的全氟辛烷磺酸的符合性检测，提供了波罗的海国家的发生数据。

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来源期刊

Food Analytical Methods 农林科学-食品科技

CiteScore

6.00

自引率

3.40%

发文量

244

审稿时长

3.1 months

期刊介绍： Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.