Hierarchical TiO2–Ag/hydrogel coating used for outstanding antifouling detection of serotonin

IF 2.8 4区工程技术 Q2 POLYMER SCIENCE

Macromolecular Research Pub Date : 2024-02-28 DOI:10.1007/s13233-024-00251-z

Xiaoyan He, Shuo Ma, Nan Sun, Miaomiao Hou, Zheping Tan, Runze Cao

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引用次数: 0

Abstract

Serotonin (5-HT) is an important neurotransmitter in vivo, regulating almost all human behavior and cognitive processes. Antifouling surface that can prevent undesirable adhesion is a key factor in the detection of 5-HT, hydrogels are considered as excellent candidates for non-fouling materials. It still remains a challenge to fabricate antifouling composites on electrode that can combine the properties of the hydrogels and surface morphology characteristics, at the same time, keeping good conductivity of the electrode. Herein, we report a new antifouling electrochemical biosensor for 5-HT detection. Using the photocatalytic activity of TiO₂ and the conductivity of Ag nanoparticles, the antifouling layer of P(VPA-SBMA-GMA) hydrogel was formed by in situ polymerization on the surface of hierarchical nanoscale TiO₂–Ag nanocomposite, 5-HT aptamers were further bound on the surface of the hydrogel for specific recognition. With these advantages, the constructed sensor had a wide detection range (0.5 pM–100 nM) and a lower detection limit (5 fM) for 5-HT.

Graphical abstract

Manufacturing process, material characterization and effect DPV diagram of a new electrochemical aptamer sensor.

Abstract Image

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用于血清素杰出防污检测的分层 TiO2-Ag/水凝胶涂层

羟色胺（5-HT）是一种重要的体内神经递质，几乎调节着人类所有的行为和认知过程。能防止不良粘附的防污表面是检测 5-HT 的关键因素，水凝胶被认为是防污材料的最佳候选材料。如何在电极上制造防污复合材料，使其既能结合水凝胶的特性和表面形态特征，又能保持电极的良好导电性，仍然是一项挑战。在此，我们报告了一种用于检测 5-HT 的新型防污电化学生物传感器。利用 TiO2 的光催化活性和 Ag 纳米粒子的导电性，在分层纳米 TiO2-Ag 纳米复合材料表面原位聚合形成了 P（VPA-SBMA-GMA）水凝胶防污层，并在水凝胶表面进一步结合了 5-HT 对映体以实现特异性识别。利用这些优点，所构建的传感器对5-HT具有较宽的检测范围（0.5 pM-100 nM）和较低的检测限（5 fM）。

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来源期刊

Macromolecular Research 工程技术-高分子科学

CiteScore

4.70

自引率

8.30%

发文量

100

审稿时长

1.3 months

期刊介绍： Original research on all aspects of polymer science, engineering and technology, including nanotechnology Presents original research articles on all aspects of polymer science, engineering and technology Coverage extends to such topics as nanotechnology, biotechnology and information technology The English-language journal of the Polymer Society of Korea Macromolecular Research is a scientific journal published monthly by the Polymer Society of Korea. Macromolecular Research publishes original researches on all aspects of polymer science, engineering, and technology as well as new emerging technologies using polymeric materials including nanotechnology, biotechnology, and information technology in forms of Articles, Communications, Notes, Reviews, and Feature articles.