Patient Perceptions of Microbiome-Based Therapies as Novel Treatments for Mood Disorders: A Mixed Methods Study: Perceptions des patients sur les thérapies basées sur le microbiome pour les troubles de l'humeur : une étude à méthodes mixtes.

IF 3.3 3区 医学 Q2 PSYCHIATRY
Dina Moinul, Chenhui Hao, Gina Dimitropoulos, Valerie H Taylor
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引用次数: 0

Abstract

Objective: Medications are critical for treating major depressive disorder (MDD) and bipolar disorder (BD). Unfortunately, 30% to 40% of individuals do not respond well to current pharmacotherapy. Given the compelling growing body of research on the gut-brain axis, this study aims to assess patient perspectives regarding microbiome-based therapies (MBT) such as probiotics, prebiotics, dietary changes, or fecal microbiota transplantation (FMT) in the management of MDD and BD.

Methods: This single-centred observational study used quantitative and qualitative assessments to examine patient perceptions of MBT. Participants diagnosed with MDD or BD completed an anonymous questionnaire obtaining demographics, prior medication history, and symptom burden. Self-assessment questionnaires specific to each diagnosis were also used: Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR), Altman Self-Rating Mania Scale (ASRM), and General Anxiety Disorder Questionnaire (GAD-7). A logistic regression model analysed the association of MBT acceptance with disorder type, QIDS-SR, and GAD-7 scores. A bootstrap method assessed the proportion of MBT acceptance. The qualitative assessment consisted of 30-minute interviews to elicit perceptions and attitudes towards MBT.

Results: The qualitative assessment achieved information power with n = 20. Results from the 63-item MBT questionnaire (n = 43) showed probiotics (37.2%) as the top choice, followed by FMT (32.6%), dietary change (25.6%), and prebiotics (4.6%). A majority of participants (72.1%) expressed willingness to try MBT for their mood disorder, however, logistic regression analysis did not identify statistically significant predictors for MBT acceptance among disorder type, QIDS-SR, and GAD-7.

Conclusion: There is an increased focus on the gut microbiota's role in mood disorders' etiology and treatment. Promising research and patient interest underscore the necessity for exploring and educating on patient perspectives and the factors influencing attitudes towards MBT.

患者对微生物疗法作为情绪障碍新疗法的看法:混合方法研究。
目的:药物是治疗重度抑郁障碍(MDD)和双相情感障碍(BD)的关键。遗憾的是,有 30% 至 40% 的患者对目前的药物疗法反应不佳。鉴于有关肠道-大脑轴的研究日益增多,本研究旨在评估患者对基于微生物组的疗法(MBT)(如益生菌、益生元、饮食改变或粪便微生物群移植(FMT))在治疗 MDD 和 BD 方面的看法:这项单中心观察性研究采用定量和定性评估方法来考察患者对微生物群疗法的看法。被诊断为 MDD 或 BD 的参与者填写了一份匿名调查问卷,调查内容包括人口统计学、既往用药史和症状负担。此外,还使用了针对每种诊断的自我评估问卷:抑郁症状快速自评量表(QIDS-SR)、奥特曼躁狂症自评量表(ASRM)和一般焦虑症问卷(GAD-7)。逻辑回归模型分析了接受 MBT 与障碍类型、QIDS-SR 和 GAD-7 评分之间的关系。自举法评估了接受 MBT 的比例。定性评估包括 30 分钟的访谈,以了解对 MBT 的看法和态度:定性评估的信息量为 n = 20。63 项 MBT 问卷(n = 43)的结果显示,益生菌(37.2%)是首选,其次是 FMT(32.6%)、饮食改变(25.6%)和益生元(4.6%)。大多数参与者(72.1%)表示愿意尝试甲基溴治疗其情绪障碍,然而,逻辑回归分析并未在障碍类型、QIDS-SR 和 GAD-7 中发现对甲基溴治疗接受度有统计学意义的预测因素:结论:人们越来越关注肠道微生物群在情绪障碍的病因和治疗中的作用。有前景的研究和患者的兴趣强调了探索和教育患者观点以及影响对 MBT 态度的因素的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
7.00
自引率
2.50%
发文量
69
审稿时长
6-12 weeks
期刊介绍: Established in 1956, The Canadian Journal of Psychiatry (The CJP) has been keeping psychiatrists up-to-date on the latest research for nearly 60 years. The CJP provides a forum for psychiatry and mental health professionals to share their findings with researchers and clinicians. The CJP includes peer-reviewed scientific articles analyzing ongoing developments in Canadian and international psychiatry.
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