Unusual Breast Metastasis from Atypical Lung Carcinoid on 68Ga-DOTATATE PET/CT.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Current Medical Imaging Reviews Pub Date : 2024-02-26 DOI:10.2174/0115734056279419240216093312

Berna Okudan, Bedri Seven, Aslıhan Yıldırım, Aynur Albayrak

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引用次数: 0

Abstract

Background: Atypical carcinoid (AC) is one of the rarest lung neuroendocrine tumors (NETs) that rarely metastasize to the breast, and only a few cases have been reported in the literature. Positron emission tomography/computed tomography (PET/CT) with somatostatin analogs (SSAs) labeled with Gallium-68 (68Ga) now represents the gold standard for diagnosis and management of NETs. A case of an unusual metastasis to the breast from an AC detected by 68Ga-DOTATATE PET/CT was reported.

Case presentation: A 73-year-old woman was presented with a right breast lesion found on mammography screening, which revealed a metastatic neuroendocrine tumor by histopathological analysis with a tru-cut biopsy. Subsequently, 68Ga-DOTATATE PET/CT imaging performed for the initial evaluation showed increased radiotracer uptake in the lesion in the right breast as well as the nodular lesion in the middle lobe of the right lung, which was histologically confirmed to be AC.

Conclusion: Metastasis of uncommon AC of the lung to the breast is extremely rare. However, it is essential to properly differentiate metastatic tumors from primary disease due to differences in clinical management and prognosis, and 68Ga-DOTATATE PET/CT is a unique diagnostic tool with the advantage of whole-body imaging.

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68Ga-DOTATATE正电子发射计算机断层扫描（PET/CT）显示非典型肺癌的异常乳腺转移。

背景：非典型类癌（AC）是最罕见的肺部神经内分泌肿瘤（NET）之一，很少转移至乳房，文献中仅有少数病例报道。目前，使用镓-68（68Ga）标记的体生长激素类似物（SSA）进行正电子发射断层扫描/计算机断层扫描（PET/CT）是诊断和治疗NET的金标准。本研究报告了一例通过 68Ga-DOTATATE PET/CT 检测到的不寻常的 AC 转移至乳房的病例：病例介绍：一名 73 岁的妇女在接受乳房 X 射线检查时发现右侧乳房有病变，经组织病理学分析和真切活检发现为转移性神经内分泌肿瘤。随后，为初步评估而进行的68Ga-DOTATATE PET/CT成像显示，右侧乳房病变和右肺中叶结节性病变的放射性示踪剂摄取增加，经组织学证实为AC：结论：不常见的肺部 AC 转移至乳房极为罕见。68Ga-DOTATATE PET/CT 是一种独特的诊断工具，具有全身成像的优势。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Imaging Reviews 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

246

审稿时长

1 months

期刊介绍： Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.