Comparative Performance of Susceptibility Map-Weighted MRI According to the Acquisition Planes in the Diagnosis of Neurodegenerative Parkinsonism.

IF 4.4 2区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Korean Journal of Radiology Pub Date : 2024-03-01 DOI:10.3348/kjr.2023.0920

Suiji Lee, Chong Hyun Suh, Sungyang Jo, Sun Ju Chung, Hwon Heo, Woo Hyun Shim, Jongho Lee, Ho Sung Kim, Sang Joon Kim, Eung Yeop Kim

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引用次数: 0

Abstract

Objective: To evaluate the diagnostic performance of susceptibility map-weighted imaging (SMwI) taken in different acquisition planes for discriminating patients with neurodegenerative parkinsonism from those without.

Materials and methods: This retrospective, observational, single-institution study enrolled consecutive patients who visited movement disorder clinics and underwent brain MRI and ¹⁸F-FP-CIT PET between September 2021 and December 2021. SMwI images were acquired in both the oblique (perpendicular to the midbrain) and the anterior commissure-posterior commissure (AC-PC) planes. Hyperintensity in the substantia nigra was determined by two neuroradiologists. ¹⁸F-FP-CIT PET was used as the reference standard. Inter-rater agreement was assessed using Cohen's kappa coefficient. The diagnostic performance of SMwI in the two planes was analyzed separately for the right and left substantia nigra. Multivariable logistic regression analysis with generalized estimating equations was applied to compare the diagnostic performance of the two planes.

Results: In total, 194 patients were included, of whom 105 and 103 had positive results on ¹⁸F-FP-CIT PET in the left and right substantia nigra, respectively. Good inter-rater agreement in the oblique (κ = 0.772/0.658 for left/right) and AC-PC planes (0.730/0.741 for left/right) was confirmed. The pooled sensitivities for two readers were 86.4% (178/206, left) and 83.3% (175/210, right) in the oblique plane and 87.4% (180/206, left) and 87.6% (184/210, right) in the AC-PC plane. The pooled specificities for two readers were 83.5% (152/182, left) and 82.0% (146/178, right) in the oblique plane, and 83.5% (152/182, left) and 86.0% (153/178, right) in the AC-PC plane. There were no significant differences in the diagnostic performance between the two planes (P > 0.05).

Conclusion: There are no significant difference in the diagnostic performance of SMwI performed in the oblique and AC-PC plane in discriminating patients with parkinsonism from those without. This finding affirms that each institution may choose the imaging plane for SMwI according to their clinical settings.

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神经退行性帕金森病诊断中不同采集平面的易感性图加权磁共振成像的性能比较

目的评估在不同采集平面拍摄的易感图谱加权成像（SMwI）在鉴别神经退行性帕金森病患者与非神经退行性帕金森病患者方面的诊断性能：这项回顾性、观察性、单一机构研究纳入了2021年9月至2021年12月期间到运动障碍诊所就诊并接受脑磁共振成像和18F-FP-CIT PET检查的连续患者。在斜面（垂直于中脑）和前会厌-后会厌（AC-PC）平面采集了 SMwI 图像。黑质的高强度由两名神经放射学专家确定。18F-FP-CIT PET 用作参考标准。使用科恩卡帕系数评估评分者之间的一致性。分别分析了 SMwI 在两个平面上对左右黑质的诊断性能。采用广义估计方程进行多变量逻辑回归分析，以比较两个平面的诊断性能：结果：共纳入 194 例患者，其中 105 例和 103 例患者的左侧和右侧黑质 18F-FP-CIT PET 检查结果呈阳性。斜面（左/右κ=0.772/0.658）和AC-PC平面（左/右κ=0.730/0.741）的评分者间一致性良好。两名读者的汇总灵敏度在斜面上分别为 86.4%（178/206，左侧）和 83.3%（175/210，右侧），在 AC-PC 平面上分别为 87.4%（180/206，左侧）和 87.6%（184/210，右侧）。两名读者的集合特异性在斜面上分别为 83.5%（152/182，左）和 82.0%（146/178，右），在 AC-PC 平面上分别为 83.5%（152/182，左）和 86.0%（153/178，右）。两个平面的诊断结果无明显差异（P>0.05）：结论：在斜面和 AC-PC 平面上进行的 SMwI 对帕金森病患者和非帕金森病患者的诊断效果没有明显差异。这一发现证实，各机构可根据其临床环境选择 SMwI 的成像平面。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Radiology 医学-核医学

CiteScore

10.60

自引率

12.50%

发文量

141

审稿时长

1.3 months

期刊介绍： The inaugural issue of the Korean J Radiol came out in March 2000. Our journal aims to produce and propagate knowledge on radiologic imaging and related sciences. A unique feature of the articles published in the Journal will be their reflection of global trends in radiology combined with an East-Asian perspective. Geographic differences in disease prevalence will be reflected in the contents of papers, and this will serve to enrich our body of knowledge. World''s outstanding radiologists from many countries are serving as editorial board of our journal.