Effect of Siphon Morphology on the Risk of C7 Segment Aneurysm Formation : A Case-control CFD Study.

IF 2.8 3区医学 Q2 Medicine

Clinical Neuroradiology Pub Date : 2024-06-01 Epub Date: 2024-02-28 DOI:10.1007/s00062-024-01394-3

Ying Wang, Bo Chen, Laixin Song, Yuzhe Li, Ming Xu, Tianxiang Huang, Feiyue Zeng

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引用次数: 0

Abstract

Purpose: Tortuosity of the internal carotid artery (ICA) is associated with intracranial aneurysms (IAs). The siphon is the most curved segment of the ICA, but its morphology has controversial effects on IAs. This study aimed to explore the morphometric features of the siphon and the potential hemodynamic mechanisms that may affect C7 aneurysm formation.

Methods: In this study 32 patients with C7 aneurysms diagnosed at Xiangya Hospital between 2019 and 2021 and 32 control subjects were enrolled after propensity score matching. Computed tomography angiography (CTA) images were acquired to measure morphologic features, and then, by combining clinical data, simplified carotid siphon models were constructed, and computational fluid dynamics (CFD) analysis was performed.

Results: The presence of C7 aneurysms was associated with the height of the C4-C6 curved arteries (odds ratio [OR] 0.028, 95% confidence interval [CI] 0.003-0.201; P < 0.001). The heights of the C4-C6 curved arteries in the aneurysm group were significantly shorter than those in the control group. The CFD analysis revealed that shorter C4-C6 bends led to greater blood velocity and pressure in the C7 segment arteries.

Conclusion: A shorter C4-C6 bend was associated with distal C7 aneurysm formation, and an elaborate hemodynamic mechanism may underlie this association.

Abstract Image

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虹吸管形态对 C7 节段动脉瘤形成风险的影响：病例对照 CFD 研究。

目的：颈内动脉（ICA）的迂曲与颅内动脉瘤（IAs）有关。虹吸管是颈内动脉最弯曲的部分，但其形态对颅内动脉瘤的影响存在争议。本研究旨在探讨虹吸管的形态特征以及可能影响 C7 动脉瘤形成的潜在血液动力学机制：本研究中，湘雅医院在2019年至2021年期间确诊的32例C7动脉瘤患者和32例对照受试者经倾向评分匹配后入选。采集计算机断层扫描血管造影（CTA）图像测量形态学特征，然后结合临床数据，构建简化颈动脉虹吸管模型，并进行计算流体动力学（CFD）分析：结果：C7动脉瘤的存在与C4-C6弯曲动脉的高度有关（几率比[OR]0.028，95%置信区间[CI]0.003-0.201；P 结论：C7动脉瘤的存在与C4-C6弯曲动脉的高度有关：较短的C4-C6弯曲动脉与C7远端动脉瘤的形成有关，这种关联可能是一种复杂的血液动力学机制造成的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neuroradiology Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

4.90

自引率

3.60%

发文量

期刊介绍： Clinical Neuroradiology provides current information, original contributions, and reviews in the field of neuroradiology. An interdisciplinary approach is accomplished by diagnostic and therapeutic contributions related to associated subjects. The international coverage and relevance of the journal is underlined by its being the official journal of the German, Swiss, and Austrian Societies of Neuroradiology.