Frequency of cognitive impairment in patients with neuromyelitis optica spectrum disorder in Mexico.

IF 2.5 Q2 CLINICAL NEUROLOGY

Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2024-02-25 eCollection Date: 2024-01-01 DOI:10.1177/20552173241231678

Edgar R Valdivia-Tangarife, Fernando Cortés-Enríquez, Alejandra Morlett-Paredes, Teresita Villaseñor-Cabrera, Jorge I Gámez-Nava, Mario A Mireles-Ramírez, Laura González-López, Miguel Á Macías-Islas

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Abstract

Background: Between 29% and 67% of neuromyelitis optica spectrum disorder patients have cognitive alterations.

Objective: To assess the frequency of cognitive impairment in patients with neuromyelitis optica spectrum disorder in Mexico using the Brief International Cognitive Assessment for Multiple Sclerosis.

Methods: We evaluated 40 neuromyelitis optica spectrum disorder patients and 40 healthy controls from Mexico.

Results: 28 (70.0%) patients with neuromyelitis optica spectrum disorder had cognitive impairment in two or more cognitive domains. Student´s T test showed statistically poor performance by neuromyelitis optica spectrum disorder patients compared to healthy controls on all three neuropsychological test scores. This significant difference was observed on the Symbols Digit Modalities Test (t = 8.875; p ≤ 0.001); California Verbal Learning Test-II memory (t = 10.418; p ≤ 0.001); and Brief Visuospatial Memory Test Revised (t = 6.123; p ≤ 0.001).

Conclusions: This study showed that 70% of neuromyelitis optica spectrum disorder patients exhibited cognitive impairment in two or more cognitive domains. Determining the frequency of cognitive impairment will guide the decision of Neuropsychologists in planning cognitive rehabilitation across various domains.

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墨西哥神经脊髓炎视网膜谱系障碍患者认知障碍的发生率。

背景：29%到67%的神经脊髓炎视网膜频谱障碍患者有认知改变：29%至67%的神经脊髓炎视网膜频谱障碍患者存在认知改变：使用多发性硬化症国际认知评估简表评估墨西哥神经脊髓炎视网膜频谱障碍患者认知障碍的频率：结果：28 名（70.0%）神经脊髓炎视网膜频谱障碍患者在两个或两个以上认知领域存在认知障碍。学生 T 检验显示，与健康对照组相比，神经脊髓炎视谱系障碍患者在所有三项神经心理测试中的成绩都较差。在符号数字模型测试（t = 8.875；p ≤ 0.001）、加州言语学习测试-II记忆（t = 10.418；p ≤ 0.001）和简明视觉空间记忆测试修订版（t = 6.123；p ≤ 0.001）上都观察到了这一明显差异：这项研究表明，70%的神经脊髓炎视网膜频谱障碍患者在两个或两个以上的认知领域表现出认知障碍。确定认知障碍的频率将为神经心理学家规划不同领域的认知康复提供指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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