The Young Investigator Committee of the International Xenotransplantation Association-Perspective of advancements in the field in 2023.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

ACS Applied Electronic Materials Pub Date : 2024-01-01 DOI:10.1111/xen.12845

Corbin E Goerlich, Shani S Kamberi, Joseph Ladowski, Antonio Citro, Margaret Connolly, Konrad Fischer, Evelyn J Salvaris, Avneesh K Singh, Yi Wang, Jeffrey Stern, Raphael P H Meier

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Abstract

The 2023 IXA conference, hosted in San Diego, CA, brimmed with excitement against the backdrop of recent innovations in both the pre-clinical and clinical realms with several first-in-human applications of xenotransplantation. The theme, "Pigs are flying," alluded to the adage that xenotransplantation would only become a clinical reality "when pigs fly," suggesting a day that might never come. The event witnessed significant attendance, with 600 participants-the highest in the history of an IXA-IPITA joint congress. Among the attendees were members of the Food and Drug Administration (FDA), the National Institutes of Health (NIH), and corporate sponsors deeply engaged in the field. We summarize the latest topics from the congress, ranging from the pros/cons of decedent models of xenotransplantation and genetic engineering of porcine heart valves, solid organs, and cells for clinical translation and their regulatory and ethical landscape.

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国际异种器官移植协会青年研究员委员会--展望 2023 年该领域的发展。

2023 年国际器官移植协会会议在加利福尼亚州圣迭戈举行，会议以临床前和临床领域的最新创新为背景，介绍了异种器官移植在人体中的首次应用。会议的主题是 "猪在飞"，暗指异种移植只有在 "猪会飞的时候 "才会成为临床现实，这意味着这一天可能永远不会到来。本次大会参会人数众多，共有 600 人参加，是 IXA-IPITA 联合大会历史上参会人数最多的一次。与会者包括食品药品管理局 (FDA)、美国国立卫生研究院 (NIH) 的成员以及深耕该领域的企业赞助商。我们总结了大会的最新议题，包括异种移植的尸体模型和猪心脏瓣膜基因工程、实体器官和细胞用于临床转化的利弊及其监管和伦理状况。

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来源期刊

ACS Applied Electronic Materials Multiple-

CiteScore

7.20

自引率

4.30%

发文量

567