Isolated Cutaneous Granuloma Caused by Candida Parapsilosis: Case Report and Literature Review.

IF 3.6 3区生物学 Q2 MYCOLOGY

Mycopathologia Pub Date : 2024-02-26 DOI:10.1007/s11046-023-00812-3

Xinyu Yang, Xingji Jin, Zhusheng Yang, Youxue Wang, Aihua Wei, Xiumin Yang

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Abstract

Candidal granuloma is an uncommon type of deep chronic cutaneous candidiasis. Candida albican is the most common causative pathogen for candidal granuloma. We report herein the original case of a 69-year-old Chinese woman presented with a 3-year of painful cutaneous lesion on the back of left hand. Physical examination revealed a 4 × 5 cm large infiltrative reddish plaque with unclear boundaries. The yellow-white crusts were observed on the uneven surface of plaque. Histopathological examination of biopsy tissue revealed that yeast cells and the horizontal section of hyphae in the dermis by hematoxylin eosin staining and periodic acid-Schiff staining. Finally, the pathogen was identified as Candida parapsilosis by mycological examination and molecular identification. The patient was treated with itraconazole oral 200 mg twice daily combined with topical terbinafine hydrochloride cream for 2 months. The lesions were fully resolved and no recurrence was observed. Since the cutaneous infection caused by C. parasilosis were rarely reported, we also reviewed all 11 cases of cutaneous infection caused by C. parapsilosis in the PubMed. Our study highlighted that chronic unilateral infiltrated plaques or ulcers should be aware of the occurrence of fungal granuloma including candidal granuloma especially in immunocompromised patients.

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由副丝状念珠菌引起的孤立性皮肤肉芽肿：病例报告与文献综述

念珠菌肉芽肿是一种不常见的深部慢性皮肤念珠菌病。白色念珠菌是念珠菌肉芽肿最常见的致病菌。我们在此报告一例原始病例，患者为一名 69 岁的中国女性，左手背皮肤疼痛 3 年。体检发现一个 4 × 5 厘米大的浸润性淡红色斑块，边界不清。斑块表面凹凸不平，有黄白色结痂。活检组织的组织病理学检查显示，苏木精伊红染色和周期性酸-希夫染色显示真皮层中有酵母细胞和水平切片的菌丝。最后，通过真菌学检查和分子鉴定，确定病原体为副丝状念珠菌。患者接受了伊曲康唑口服，每次 200 毫克，每天两次，并外用盐酸特比萘芬乳膏治疗 2 个月。皮损完全消退，未见复发。由于寄生虫引起的皮肤感染鲜有报道，我们还查阅了 PubMed 上所有 11 例由副丝虫引起的皮肤感染病例。我们的研究强调，慢性单侧浸润性斑块或溃疡应警惕真菌肉芽肿（包括念珠菌肉芽肿）的发生，尤其是免疫力低下的患者。

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来源期刊

Mycopathologia 生物-真菌学

CiteScore

6.80

自引率

3.60%

发文量

审稿时长

3 months

期刊介绍： Mycopathologia is an official journal of the International Union of Microbiological Societies (IUMS). Mycopathologia was founded in 1938 with the mission to ‘diffuse the understanding of fungal diseases in man and animals among mycologists’. Many of the milestones discoveries in the field of medical mycology have been communicated through the pages of this journal. Mycopathologia covers a diverse, interdisciplinary range of topics that is unique in breadth and depth. The journal publishes peer-reviewed, original articles highlighting important developments concerning medically important fungi and fungal diseases. The journal highlights important developments in fungal systematics and taxonomy, laboratory diagnosis of fungal infections, antifungal drugs, clinical presentation and treatment, and epidemiology of fungal diseases globally. Timely opinion articles, mini-reviews, and other communications are usually invited at the discretion of the editorial board. Unique case reports highlighting unprecedented progress in the diagnosis and treatment of fungal infections, are published in every issue of the journal. MycopathologiaIMAGE is another regular feature for a brief clinical report of potential interest to a mixed audience of physicians and laboratory scientists. MycopathologiaGENOME is designed for the rapid publication of new genomes of human and animal pathogenic fungi using a checklist-based, standardized format.