Renal dysfunction in routine proton-pump inhibitor use may be linked to comorbidities: A real-world observational study.

IF 2 Q3 GASTROENTEROLOGY & HEPATOLOGY
Indian Journal of Gastroenterology Pub Date : 2024-12-01 Epub Date: 2024-02-26 DOI:10.1007/s12664-023-01515-9
Adeshkumar Andhale, Philip Abraham, Pavan Dhoble, Devendra Desai, Anand Joshi, Tarun Gupta, Jatin Kothari, Nikhil Bhangale
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引用次数: 0

Abstract

Introduction: The use of proton-pump inhibitors (PPI) is linked with infrequent but serious adverse events, including acute kidney injury, chronic kidney disease (CKD) and progression of CKD. Data on renal safety in routine use of PPI are more relevant to clinical practice. We studied whether such use of PPI is associated with renal dysfunction.

Methods: Patients taking PPI for at least six weeks had serum creatinine tested pre (n = 200) and post (n = 180) recruitment. These patients were then advised to follow-up: those taking PPI for at least 90 days in the next six months (n = 77) and at least another 90 days in the following six months (n = 50), had serum creatinine tested at such follow-up. Renal dysfunction was defined as any increase in serum creatinine level above baseline.

Results: The 200 patients recruited had mean age 39.6 (SD 9.2) years. Ninety-eight (49%) patients had a history of previous PPI use (median six months; interquartile range [IQR] 3-24). Only 20 (11.1%) patients at six weeks, 11 (14.3%) at six months and six (12%) at one year had increase in creatinine level; a majority of them had less than 0.3 mg/dL increase. Ten of these 20 (six weeks), five of 11 (six months) and five of six (one year) had other risk factors for renal dysfunction. No patient developed CKD during the study period.

Conclusions: Mild and non-progressive increase in serum creatinine occurred in 10% to 15% of patients on routine PPI use. A majority of them had other risk factors. Small sample size and short follow-up duration are a few limitations of this study.

常规使用质子泵抑制剂的肾功能障碍可能与合并症有关:一项真实世界观察研究。
简介:质子泵抑制剂(PPI)的使用与不常见但严重的不良事件有关,包括急性肾损伤、慢性肾病(CKD)和 CKD 的恶化。常规使用 PPI 时的肾脏安全性数据与临床实践更为相关。我们研究了使用 PPI 是否与肾功能障碍有关:方法:服用 PPI 至少六周的患者在招募前(200 人)和招募后(180 人)接受血清肌酐检测。然后建议这些患者进行随访:在接下来的六个月中至少服用 PPI 90 天的患者(77 人)和在接下来的六个月中至少再服用 PPI 90 天的患者(50 人),在随访时检测血清肌酐。肾功能障碍的定义是血清肌酐水平高于基线:招募的 200 名患者平均年龄为 39.6 岁(标准差为 9.2 岁)。98名患者(49%)曾使用过 PPI(中位数为 6 个月;四分位数间距 [IQR] 3-24)。只有 20 名(11.1%)患者在六周、11 名(14.3%)患者在六个月和 6 名(12%)患者在一年后出现肌酐水平升高;其中大多数患者的肌酐升高幅度小于 0.3 毫克/分升。这 20 人中有 10 人(6 周)、11 人中有 5 人(6 个月)和 6 人中有 5 人(1 年)有其他肾功能障碍的危险因素。在研究期间,没有患者发展为慢性肾脏病:结论:10%-15%的常规服用 PPI 的患者会出现轻度、非进行性的血清肌酐升高。他们中的大多数人都有其他风险因素。样本量小、随访时间短是这项研究的一些局限性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Indian Journal of Gastroenterology
Indian Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
3.90
自引率
10.00%
发文量
73
期刊介绍: The Indian Journal of Gastroenterology aims to help doctors everywhere practise better medicine and to influence the debate on gastroenterology. To achieve these aims, we publish original scientific studies, state-of -the-art special articles, reports and papers commenting on the clinical, scientific and public health factors affecting aspects of gastroenterology. We shall be delighted to receive articles for publication in all of these categories and letters commenting on the contents of the Journal or on issues of interest to our readers.
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