Colon cancer survival in the elderly without curative surgery.

IF 1.1 4区医学 Q3 SURGERY

Annals of the Royal College of Surgeons of England Pub Date : 2024-09-01 Epub Date: 2024-02-26 DOI:10.1308/rcsann.2023.0059

J Franklyn, A Poole, I Lindsey

{"title":"Colon cancer survival in the elderly without curative surgery.","authors":"J Franklyn, A Poole, I Lindsey","doi":"10.1308/rcsann.2023.0059","DOIUrl":null,"url":null,"abstract":"Introduction: The aim of this study was to chart the natural history of elderly patients with colon cancer who are managed nonoperatively, with the primary outcome being life expectancy from diagnosis to death.Methods: This was a retrospective analysis of patients aged 80 years and above diagnosed with colon cancer in a tertiary care referral hospital in England between 1 January 2012 and 31 December 2017.Results: Thirty-two patients were diagnosed with non-metastatic colon cancer and managed non-operatively. The median age of patients in this study was 86 years. The group had a median Charlson Comorbidity Index of 7 (range 6-12) and the median frailty score was 6 (range 3-8). Progression to metastatic disease was identified in two patients; two further patients showed locoregional progression of cancer and therefore required palliative surgical intervention. Survival of these patients ranged from 105 to 1,782 days with a median life expectancy of 586 days. Place of death was identified in 15/31 patients: 4 (27%) died in hospital, 12 (38%) died at home and 15 (47%) died in a nursing or residential home; data were missing for 1 patient (3%).Conclusions: Nonoperative management of elderly patients with colon cancer yields reasonable life expectancy and a low risk of life-threatening local complications.","PeriodicalId":8088,"journal":{"name":"Annals of the Royal College of Surgeons of England","volume":" ","pages":"592-595"},"PeriodicalIF":1.1000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11365724/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of the Royal College of Surgeons of England","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1308/rcsann.2023.0059","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/2/26 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: The aim of this study was to chart the natural history of elderly patients with colon cancer who are managed nonoperatively, with the primary outcome being life expectancy from diagnosis to death.

Methods: This was a retrospective analysis of patients aged 80 years and above diagnosed with colon cancer in a tertiary care referral hospital in England between 1 January 2012 and 31 December 2017.

Results: Thirty-two patients were diagnosed with non-metastatic colon cancer and managed non-operatively. The median age of patients in this study was 86 years. The group had a median Charlson Comorbidity Index of 7 (range 6-12) and the median frailty score was 6 (range 3-8). Progression to metastatic disease was identified in two patients; two further patients showed locoregional progression of cancer and therefore required palliative surgical intervention. Survival of these patients ranged from 105 to 1,782 days with a median life expectancy of 586 days. Place of death was identified in 15/31 patients: 4 (27%) died in hospital, 12 (38%) died at home and 15 (47%) died in a nursing or residential home; data were missing for 1 patient (3%).

Conclusions: Nonoperative management of elderly patients with colon cancer yields reasonable life expectancy and a low risk of life-threatening local complications.

查看原文本刊更多论文

未接受根治性手术的老年人结肠癌存活率。

简介：本研究的目的是记录接受非手术治疗的老年结肠癌患者的自然病史，主要结果是患者从确诊到死亡的预期寿命：本研究的目的是记录接受非手术治疗的老年结肠癌患者的自然病史，主要结果是患者从确诊到死亡的预期寿命：这是一项回顾性分析，研究对象是2012年1月1日至2017年12月31日期间在英国一家三级医疗转诊医院确诊的80岁及以上结肠癌患者：32名患者被诊断为非转移性结肠癌，并接受了非手术治疗。本研究中患者的中位年龄为 86 岁。该组患者的夏尔森合并症指数中位数为 7（范围 6-12），虚弱评分中位数为 6（范围 3-8）。有两名患者的病情发展为转移性疾病；另有两名患者的癌症出现局部进展，因此需要姑息性手术干预。这些患者的生存期从 105 天到 1782 天不等，中位预期寿命为 586 天。15/31 例患者的死亡地点已经确定：4人（27%）死于医院，12人（38%）死于家中，15人（47%）死于疗养院或养老院；1人（3%）数据缺失：结论：对老年结肠癌患者进行非手术治疗可获得合理的预期寿命，且出现危及生命的局部并发症的风险较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of the Royal College of Surgeons of England Medicine-Surgery

CiteScore

2.40

自引率

0.00%

发文量

316

期刊介绍： The Annals of The Royal College of Surgeons of England is the official scholarly research journal of the Royal College of Surgeons and is published eight times a year in January, February, March, April, May, July, September and November. The main aim of the journal is to publish high-quality, peer-reviewed papers that relate to all branches of surgery. The Annals also includes letters and comments, a regular technical section, controversial topics, CORESS feedback and book reviews. The editorial board is composed of experts from all the surgical specialties.