The global burden of cervical cancer requiring surgery: database estimates

IF 3.1 2区医学 Q3 IMMUNOLOGY

Infectious Agents and Cancer Pub Date : 2024-02-26 DOI:10.1186/s13027-023-00562-3

Emma R Allanson, Syed Nabeel Zafar, Chidinma P Anakwenze, Kathleen M Schmeler, Edward L Trimble, Surbhi Grover

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引用次数: 0

Abstract

Scaling up surgical services for cervical cancer in low and middle income countries requires quantification of the need for those services. The aim of this study was to estimate the global burden of cervical cancer for which access to surgery is required. This was a retrospective analysis of publicly available data. Cervical cancer incidence was extracted for each country from the World Health Organization, International Agency for Research, Global Cancer Observatory. The proportion of cases requiring surgery was extrapolated from the United States Surveillance, Epidemiology and End-Result database. The need for cervical cancer surgery was tested against development indicators. Data were available for 175 countries, representing 2.9 billion females aged 15 and over. There were approximately 566,911 women diagnosed with cervical cancer (95% CI 565,462–568,360). An estimated 56.9% of these women (322,686) would require surgery for diagnosis, treatment or palliation (95% CI 321,955 − 323,417). Cervical cancers for which surgery is required represent less than 1% of cancers in high income countries, and nearly 10% of cancers in low income countries. At least 300,000 cervical cancer cases worldwide require access to surgical services annually. Gathering data on available cervical cancer surgery services in LMIC are a critical next step.

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需要手术治疗的宫颈癌的全球负担：数据库估算值

要在中低收入国家推广宫颈癌手术服务，就必须对这些服务的需求进行量化。本研究旨在估算需要接受手术治疗的宫颈癌的全球负担。这是一项对公开数据的回顾性分析。每个国家的宫颈癌发病率都是从世界卫生组织、国际研究机构、全球癌症观察站中提取的。需要手术治疗的病例比例是从美国监测、流行病学和最终结果数据库中推算出来的。宫颈癌手术需求根据发展指标进行测试。数据来自 175 个国家，代表 29 亿 15 岁及以上女性。约有 566,911 名妇女被诊断出患有宫颈癌（95% CI 565,462-568,360 人）。据估计，其中 56.9% 的妇女（322,686 人）需要手术进行诊断、治疗或缓解（95% CI 321,955 - 323,417）。在高收入国家，需要手术治疗的宫颈癌不到癌症总数的 1%，而在低收入国家则接近 10%。全世界每年至少有 30 万例宫颈癌患者需要接受手术治疗。收集低收入和中等收入国家现有宫颈癌手术服务的数据是下一步工作的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.