Expression of TNF-α, omentin-1, and IL-6 before and after adjunctive treatment with a bioactive antimicrobial peptide periodontal gel

IF 2.7 3区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Journal of Oral Pathology & Medicine Pub Date : 2024-02-25 DOI:10.1111/jop.13518

Bo Zhang, Lulu Wang, Chang Liu

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引用次数: 0

Abstract

Background

The objective of this study was to evaluate and compare the expression levels of TNF-α, omentin-1, and IL-6 in periodontitis patients before and after treatment with biological antimicrobial peptide (AMP) periodontal gel.

Methods

There involved 86 periodontitis patients admitted to our hospital from January 2020 to March 2021. They were equally and randomly distributed into the study group and the control group. The efficacy and adverse reactions were compared between the two groups after treatment, Additionally, the sulcus bleeding index (SBI), plaque index (PLI), gingival index (GI), periodontal probing depth (PD), and levels of TNF-α, omentin-1, and IL-6 were measured before and after treatment.

Results

After treatment, the total effective rate of the study group was significantly higher than that of the control group (p < 0.05), while the scores of four indicators (SBI, PLI, GI, and PD) and the levels of TNF-α, omentin-1, and IL-6 in the study group were evidently lower than the control group (p < 0.05). The study group had 1 case of mild irritant reaction, with an adverse reaction rate of 2.33% (1/43). And the control group had 1 case of nausea and 1 case of allergy, with an adverse reaction rate of 4.65% (2/43). The adverse reactions demonstrated no statistical difference between the two groups (χ² = 0.345, p = 0.557).

Conclusions

The levels of TNF-α and IL-6 were highly expressed before the auxiliary therapy of biological AMP periodontal gel for periodontitis, alongside low expression of omentin-1. Subsequently, the biological antibacterial polypeptide periodontal gel demonstrated efficacy in the treatment of periodontitis.

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生物活性抗菌肽牙周凝胶辅助治疗前后 TNF-α、网织蛋白-1 和 IL-6 的表达情况

背景本研究旨在评估和比较牙周炎患者在使用生物抗菌肽（AMP）牙周凝胶治疗前后TNF-α、网状素-1和IL-6的表达水平。研究组和对照组的患者人数相等，随机分配。比较两组患者治疗后的疗效和不良反应，并测定两组患者治疗前后的龈沟出血指数（SBI）、牙菌斑指数（PLI）、牙龈指数（GI）、牙周探诊深度（PD）以及TNF-α、网状素-1和IL-6的水平。结果治疗后，研究组的总有效率明显高于对照组（P <0.05），而研究组的四项指标（SBI、PLI、GI、PD）评分和 TNF-α、网状素-1、IL-6 水平明显低于对照组（P <0.05）。研究组出现 1 例轻度刺激反应，不良反应率为 2.33%（1/43）。对照组有 1 例恶心和 1 例过敏，不良反应率为 4.65%（2/43）。结论在使用生物 AMP 牙周凝胶辅助治疗牙周炎前，TNF-α 和 IL-6 的表达水平较高，而网状素-1 的表达水平较低。随后，生物抗菌多肽牙周凝胶显示出治疗牙周炎的疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Oral Pathology & Medicine 医学-病理学

CiteScore

5.90

自引率

6.10%

发文量

121

审稿时长

4-8 weeks

期刊介绍： The aim of the Journal of Oral Pathology & Medicine is to publish manuscripts of high scientific quality representing original clinical, diagnostic or experimental work in oral pathology and oral medicine. Papers advancing the science or practice of these disciplines will be welcomed, especially those which bring new knowledge and observations from the application of techniques within the spheres of light and electron microscopy, tissue and organ culture, immunology, histochemistry and immunocytochemistry, microbiology, genetics and biochemistry.