{"title":"Electrospun poly(octamethylene citrate) thermoset fibrous mat from chitin nanocrystal constructed Pickering emulsion","authors":"","doi":"10.1007/s00396-024-05238-x","DOIUrl":null,"url":null,"abstract":"<h3>Abstract</h3> <p>Poly(octamethylene citrate) (POC) is a promising bioelastomer material in tissue engineering field. However, its thermosetting characteristic reveals a big challenge to manufacture fibrous membranes via electrospinning. Herein, an Pickering emulsion, with dimethyl carbonate solution of POC prepolymer (pre-POC) as a dispersed oil phase (o), Pullulan (Pull) aqueous solution as a continuous water phase (w), and chitin nanocrystal (ChiNC) as a particle-type emulsifier, was successfully constructed and electrospun to form POC/Pull core/shell structured fibers, in which the ChiNCs did not merely reside on the core/shell interface, but moved into the POC core layer to reinforce the POC matrix. On the one hand, the core/shell structured fiber mat could be used as a double-layer drug release system to release hydrophilic drugs from outer layer and hydrophobic drugs from core layer. On the other hand, after washing off the Pull shell layer, a pure POC elastomer fiber mat was obtained, of which the mechanical properties were comparable to that of the ChiNC reinforced POC dense films.</p>","PeriodicalId":520,"journal":{"name":"Colloid and Polymer Science","volume":null,"pages":null},"PeriodicalIF":2.2000,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloid and Polymer Science","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s00396-024-05238-x","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Poly(octamethylene citrate) (POC) is a promising bioelastomer material in tissue engineering field. However, its thermosetting characteristic reveals a big challenge to manufacture fibrous membranes via electrospinning. Herein, an Pickering emulsion, with dimethyl carbonate solution of POC prepolymer (pre-POC) as a dispersed oil phase (o), Pullulan (Pull) aqueous solution as a continuous water phase (w), and chitin nanocrystal (ChiNC) as a particle-type emulsifier, was successfully constructed and electrospun to form POC/Pull core/shell structured fibers, in which the ChiNCs did not merely reside on the core/shell interface, but moved into the POC core layer to reinforce the POC matrix. On the one hand, the core/shell structured fiber mat could be used as a double-layer drug release system to release hydrophilic drugs from outer layer and hydrophobic drugs from core layer. On the other hand, after washing off the Pull shell layer, a pure POC elastomer fiber mat was obtained, of which the mechanical properties were comparable to that of the ChiNC reinforced POC dense films.
期刊介绍：
Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.
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