Terbinafine resistance in Trichophyton mentagrophytes and Trichophyton rubrum in the Czech Republic: A prospective multicentric study

IF 4.1 2区医学 Q1 DERMATOLOGY

Mycoses Pub Date : 2024-02-26 DOI:10.1111/myc.13708

Daniela Kolarczyková, Pavlína Lysková, Michaela Švarcová, Ivana Kuklová, Radim Dobiáš, Naďa Mallátová, Miroslav Kolařík, Vit Hubka

引用次数: 0

Abstract

Terbinafine, an allylamine antifungal, is crucial for treating dermatophytosis by inhibiting squalene epoxidase (SQLE) in the ergosterol biosynthetic pathway. However, resistance is emerging, particularly in India and Southeast Asia, but reports of resistance spread worldwide. Despite this, comprehensive studies on terbinafine resistance in Trichophyton are still limited.

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捷克共和国曼陀罗毛癣菌和红毛癣菌对特比萘芬的耐药性：前瞻性多中心研究

特比萘芬是一种烯丙基胺类抗真菌药，通过抑制麦角甾醇生物合成途径中的角鲨烯环氧化酶（SQLE），对治疗皮肤癣菌病至关重要。然而，耐药性正在出现，尤其是在印度和东南亚，但耐药性的报告遍布全球。尽管如此，有关毛癣菌对特比萘芬耐药性的全面研究仍然有限。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mycoses 医学-皮肤病学

CiteScore

10.00

自引率

8.20%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The journal Mycoses provides an international forum for original papers in English on the pathogenesis, diagnosis, therapy, prophylaxis, and epidemiology of fungal infectious diseases in humans as well as on the biology of pathogenic fungi. Medical mycology as part of medical microbiology is advancing rapidly. Effective therapeutic strategies are already available in chemotherapy and are being further developed. Their application requires reliable laboratory diagnostic techniques, which, in turn, result from mycological basic research. Opportunistic mycoses vary greatly in their clinical and pathological symptoms, because the underlying disease of a patient at risk decisively determines their symptomatology and progress. The journal Mycoses is therefore of interest to scientists in fundamental mycological research, mycological laboratory diagnosticians and clinicians interested in fungal infections.