Recent Trends in Nanomaterial Based Electrochemical Sensors for Drug Detection: Considering Green Assessment

IF 2.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2024-02-22 DOI:10.2174/0115680266286981240207053402

Tugba Ozer, Charles S. Henry

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Abstract

: An individual’s therapeutic drug exposure level is directly linked to corresponding clinical effects. Rapid, sensitive, inexpensive, portable and reliable devices are needed for diagnosis related to drug exposure, treatment, and prognosis of diseases. Electrochemical sensors are useful for drug monitoring due to their high sensitivity and fast response time. Also, they can be combined with portable signal read-out devices for point-of-care applications. In recent years, nanomaterials such as carbon-based, carbon-metal nanocomposites, noble nanomaterials have been widely used to modify electrode surfaces due to their outstanding features including catalytic abilities, conductivity, chemical stability, biocompatibility for development of electrochemical sensors. This review paper presents the most recent advances about nanomaterials-based electrochemical sensors including the use of green assessment approach for detection of drugs including anticancer, antiviral, anti-inflammatory, and antibiotics covering the period from 2019 to 2023. The sensor characteristics such as analyte interactions, fabrication, sensitivity, and selectivity are also discussed. In addition, the current challenges and potential future directions of the field are highlighted.

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基于纳米材料的药物检测电化学传感器的最新发展趋势：绿色评估

:个人的治疗药物暴露水平与相应的临床效果直接相关。需要快速、灵敏、廉价、便携和可靠的设备来诊断药物暴露、治疗和疾病预后。电化学传感器具有灵敏度高、响应速度快的特点，可用于药物监测。此外，电化学传感器还可与便携式信号读出设备相结合，用于护理点应用。近年来，碳基纳米材料、碳-金属纳米复合材料、惰性纳米材料等纳米材料因其催化能力、导电性、化学稳定性、生物相容性等突出特点，被广泛用于电极表面改性，以开发电化学传感器。本综述论文介绍了基于纳米材料的电化学传感器的最新进展，包括使用绿色评估方法检测抗癌、抗病毒、抗炎和抗生素等药物，时间跨度为 2019 年至 2023 年。报告还讨论了传感器的特性，如分析物相互作用、制造、灵敏度和选择性。此外，还重点介绍了该领域当前面临的挑战和潜在的未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.