Surface modification of sodium hyaluronate with dopamine to enhance emulsifying capacity and application performance

IF 2.2 4区化学 Q3 CHEMISTRY, PHYSICAL

Colloid and Polymer Science Pub Date : 2024-02-23 DOI:10.1007/s00396-024-05228-z

Qianjie Zhang, Pingli Wang, Dongmei Zhang, Shilian Zheng, Wanping Zhang

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引用次数: 0

Abstract

Hyaluronic acid (HA) is a mucopolysaccharide alternately linked by glucuronic acid and n-Acetylglucosamine as disaccharide units. This study prepared HA derivative (DA-HA) by modifying sodium hyaluronate with dopamine (DA). DA-HA had unique surface activity. By optimizing the reaction conditions systematically, DA-HA could prepare the emulsion with uniform droplets successfully. When n (COOH) /n (EDC) /n (NHS) was 1/2/4, n (HA) /n (DA) was 1/5, the reaction pH was 5.5, and the molecular weight of HA was 1350 KDa, the emulsion particles were relatively uniform. The chemical structure of DA-HA was characterized, and the results showed that DA was grafted on the HA chain through the amide bond. In addition, the effect of formula composition on the emulsifying performance of DA-HA was studied. The particle size of emulsion decreased as the concentration of DA-HA increased. When the oil-water ratio was 4/6 or 5/5, the emulsion droplets were small and uniform. When the aqueous phase was in an acidic or weakly alkaline condition, the particle size of the emulsion was smaller. The introduction of high salinity will destroy the stability of the emulsion. Meanwhile, DA-HA also had good moisturizing property and biosafety, which greatly expanded the application of HA in cosmetics.

Graphical abstract

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用多巴胺对透明质酸钠进行表面改性以提高乳化能力和应用性能

摘要透明质酸（HA）是一种以葡萄糖醛酸和正乙酰葡糖胺为双糖单位交替连接的粘多糖。本研究用多巴胺（DA）修饰透明质酸钠，制备了透明质酸衍生物（DA-HA）。DA-HA 具有独特的表面活性。通过系统优化反应条件，DA-HA 可成功制备出具有均匀液滴的乳液。当n（COOH）/n（EDC）/n（NHS）为1/2/4，n（HA）/n（DA）为1/5，反应pH为5.5，HA分子量为1350 KDa时，乳液颗粒相对均匀。对 DA-HA 的化学结构进行了表征，结果表明 DA 是通过酰胺键接枝到 HA 链上的。此外，还研究了配方组成对 DA-HA 乳化性能的影响。随着 DA-HA 浓度的增加，乳液的粒径减小。当油水比为 4/6 或 5/5 时，乳液液滴小而均匀。当水相为酸性或弱碱性时，乳液的粒径较小。引入高盐度会破坏乳液的稳定性。同时，DA-HA还具有良好的保湿性和生物安全性，大大拓展了HA在化妆品中的应用。图表摘要

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来源期刊

Colloid and Polymer Science 化学-高分子科学

CiteScore

4.60

自引率

4.20%

发文量

111

审稿时长

2.2 months

期刊介绍： Colloid and Polymer Science - a leading international journal of longstanding tradition - is devoted to colloid and polymer science and its interdisciplinary interactions. As such, it responds to a demand which has lost none of its actuality as revealed in the trends of contemporary materials science.