MYBBP1A is required for efficient replication and gene expression of herpes simplex virus 1

IF 1.9 4区 医学 Q4 IMMUNOLOGY
Moeka Nobe, Yuhei Maruzuru, Kosuke Takeshima, Naoto Koyanagi, Akihisa Kato, Yasushi Kawaguchi
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引用次数: 0

Abstract

More than 100 different herpes simplex virus 1 (HSV-1) genes belong to three major classes, and their expression is coordinately regulated and sequentially ordered in a cascade. This complex HSV-1 gene expression is thought to be regulated by various viral and host cellular proteins. A host cellular protein, Myb-binding protein 1A (MYBBP1A), has been reported to be associated with HSV-1 viral genomes in conjunction with viral and cellular proteins critical for DNA replication, repair, and transcription within infected cells. However, the role(s) of MYBBP1A in HSV-1 infections remains unclear. In this study, we examined the effects of MYBBP1A depletion on HSV-1 infection and found that MYBBP1A depletion significantly reduced HSV-1 replication, as well as the accumulation of several viral proteins. These results suggest that MYBBP1A is an important host cellular factor that contributes to HSV-1 replication, plausibly by promoting viral gene expression.

单纯疱疹病毒 1 的高效复制和基因表达需要 MYBBP1A。
100 多种不同的单纯疱疹病毒 1(HSV-1)基因分属三大类,它们的表达受到协调调控,并按顺序排列成一个级联。这种复杂的 HSV-1 基因表达被认为受到各种病毒和宿主细胞蛋白的调控。据报道,宿主细胞蛋白--Myb 结合蛋白 1A(MYBBP1A)与 HSV-1 病毒基因组有关,与病毒和细胞蛋白一起对感染细胞内的 DNA 复制、修复和转录至关重要。然而,MYBBP1A 在 HSV-1 感染中的作用仍不清楚。在这项研究中,我们研究了 MYBBP1A 缺失对 HSV-1 感染的影响,发现 MYBBP1A 缺失能显著减少 HSV-1 复制以及几种病毒蛋白的积累。这些结果表明,MYBBP1A是一种重要的宿主细胞因子,它可能通过促进病毒基因的表达来促进HSV-1的复制。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Microbiology and Immunology
Microbiology and Immunology 医学-免疫学
CiteScore
5.20
自引率
3.80%
发文量
78
审稿时长
1 months
期刊介绍: Microbiology and Immunology is published in association with Japanese Society for Bacteriology, Japanese Society for Virology, and Japanese Society for Host Defense Research. It is peer-reviewed publication that provides insight into the study of microbes and the host immune, biological and physiological responses. Fields covered by Microbiology and Immunology include:Bacteriology|Virology|Immunology|pathogenic infections in human, animals and plants|pathogenicity and virulence factors such as microbial toxins and cell-surface components|factors involved in host defense, inflammation, development of vaccines|antimicrobial agents and drug resistance of microbes|genomics and proteomics.
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