Predictive Value of NT-proBNP for New-onset Atrial Fibrillation in the Acute Phase of Myocardial Infarction.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-10-01

Zhimin Dong, Xiaoxia Hou, Caixia Guo

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引用次数: 0

Abstract

Objective: The objective of this study was to assess the predictive value of N-terminal pro-brain natriuretic peptide (NT-pro-BNP) levels on admission and new-onset atrial fibrillation (AF) in patients with acute myocardial infarction (AMI).

Methods: In this study, a retrospective cohort study design scheme was used to include a total of 291 consecutive patients who were hospitalized for AMI from July 2019 to May 2020, of whom 36 (12.4%) developed new-onset atrial fibrillation (AF) during their hospitalization, which was classified as the AF group, and the rest of the patients were in the non-AF group. The impact of NT-pro-BNP on new-onset atrial fibrillation was investigated using the general data, laboratory tests, cardiac ultrasonography, and coronary angiography results of the two groups. Logistic regression analysis was employed to investigate the effect of NT-pro-BNP on new-onset atrial fibrillation. Additionally, we analyzed the significance of NT-pro-BNP in predicting new-onset AF in AMI patients using the the area under the AUC.

Results: Univariate analysis indicated that patients in the AF group had significantly higher (P < .05) age, leukocyte count on admission, high-sensitivity C-reactive protein (hs-CRP), blood creatinine, uric acid, NT-pro-BNP, and left ventricular end-diastolic internal diameter (LVED) than those in the non-AF group. Patients in the AF group had lower blood pressure and left ventricular ejection fraction compared with the non-AF group. Logistic multifactorial regression analysis indicated that NT-pro-BNP was an independent risk factor for new-onset AF in patients with AMI (OR=2.752, 95% CI 1.352-5.602, P = .005). The area under the AUC was 0.747 (95% CI 0.655-0.84; P = .001), with a sensitivity of 64%, a specificity of 78%, and a Jordon's index of 0.458. This corresponds to an optimal cutoff value of 5374 pg/ml, suggesting that NT-pro-BNP performs well in predicting new-onset atrial fibrillation.

Conclusion: NT-pro-BNP on admission can be a useful predictor of whether new-onset atrial fibrillation occurs in patients with AMI, with good predictive value. This finding helps better to meet patients' diagnostic and therapeutic needs and provides useful clinical guidance to improve the management and prognosis of AMI patients.

本刊更多论文

NT-proBNP 对心肌梗死急性期新发心房颤动的预测价值。

研究目的本研究旨在评估急性心肌梗死（AMI）患者入院时N末端前脑钠尿肽（NT-pro-BNP）水平和新发房颤（AF）的预测价值：本研究采用回顾性队列研究设计方案，共纳入2019年7月至2020年5月期间因AMI住院的连续患者291例，其中36例（12.4%）在住院期间出现新发房颤，被划分为房颤组，其余患者为非房颤组。通过两组患者的一般数据、实验室检查、心脏超声波检查和冠状动脉造影结果，研究了NT-pro-BNP对新发房颤的影响。我们采用逻辑回归分析来研究 NT-pro-BNP 对新发心房颤动的影响。此外，我们还利用AUC下面积分析了NT-pro-BNP在预测急性心肌梗死患者新发房颤方面的意义：单变量分析表明，房颤组患者的年龄、入院时白细胞计数、高敏 C 反应蛋白（hs-CRP）、血肌酐、尿酸、NT-pro-BNP 和左心室舒张末期内径（LVED）均明显高于非房颤组患者（P < .05）。与非房颤组相比，房颤组患者的血压和左心室射血分数较低。逻辑多因素回归分析表明，NT-pro-BNP是AMI患者新发房颤的独立风险因素（OR=2.752，95% CI 1.352-5.602，P = .005）。AUC下面积为0.747（95% CI 0.655-0.84；P = .001），灵敏度为64%，特异度为78%，乔登指数为0.458。这与5374 pg/ml的最佳临界值相对应，表明NT-pro-BNP在预测新发心房颤动方面表现良好：入院时的NT-pro-BNP是预测急性心肌梗死患者是否发生新发心房颤动的有效指标，具有良好的预测价值。这一发现有助于更好地满足患者的诊断和治疗需求，并为改善急性心肌梗死患者的管理和预后提供有用的临床指导。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.