Effect of Percutaneous Balloon Compression on Trigeminal Neuralgia and Clinical Significance of NLRP3 Before and After Treatment.

IF 1.9 4区 医学 Q3 INTEGRATIVE & COMPLEMENTARY MEDICINE
Jun Li, Wenhao Wang, Wei Huang, Junming Lin, Xuefeng Zheng, Mingsheng Zhang, Zhikun Lin
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引用次数: 0

Abstract

Objective: Trigeminal neuralgia (TN) is very common in the middle-aged and elderly population and seriously affects the normal life of patients. This study aims to analyze the therapeutic effect of percutaneous balloon compression (PBC) on TN and to explore the clinical significance of NOD-like receptor thermal protein domain associated protein 3 (NLRP3), which not only can provide a reference for the clinical treatment of TN in the future, but also can help the clinic to find a reliable indicator for the assessment of TN condition.

Methods: The length of stay, total cost of hospitalization, and adverse reactions during treatment were compared between the two groups. Patients were subjected to assessments or investigations of the Barrow Neurological Institute (BNI) scale, Pittsburgh Sleep Quality Index (PSQI), Self-rating Anxiety Scale (SAS), and Self-rating Depression Scale (SDS) before and after treatment. In addition, NLRP3 in the peripheral blood of patients in the research group was measured, and the correlation of NLRP3 with BNI score and prognosis for recurrence was analyzed.

Results: The length of stay and the total cost of hospitalization were respectively (12.10±2.20) d and (26445.96±5553.78) yuan in the research group, significantly reduced than those in the control group (P < .05). And the BNI score, PSQI and SAS/SDS were lower in the research group after treatment (P < .05), but the incidence of facial numbness, herpes orofacialis and masticatory muscle weakness were higher in the research group than in the control group (P < .05). After treatment, NLRP3 decreased in the research group, which was positively correlated with BNI score (P < .05). In addition, NLRP3 showed an excellent effect in predicting recurrence.

Conclusion: PBC effectively improved the pain and negative psychological status of patients with TN, and NLRP3 was closely related to the pain of patients with TN. In the future, PBC is used in the clinic to treat TN and improve the prognosis of patients.

经皮球囊压迫对三叉神经痛的影响及治疗前后 NLRP3 的临床意义
目的:三叉神经痛(TN)在中老年人群中十分常见,严重影响患者的正常生活。本研究旨在分析经皮球囊压迫术(PBC)对TN的治疗效果,并探讨NOD样受体热蛋白结构域相关蛋白3(NLRP3)的临床意义,不仅能为今后TN的临床治疗提供参考,还能帮助临床找到评估TN病情的可靠指标:方法:比较两组患者的住院时间、住院总费用和治疗期间的不良反应。患者在治疗前后均接受了巴罗神经研究所(BNI)量表、匹兹堡睡眠质量指数(PSQI)、焦虑自评量表(SAS)和抑郁自评量表(SDS)的评估或调查。此外,还测定了研究组患者外周血中的NLRP3,并分析了NLRP3与BNI评分和复发预后的相关性:结果:研究组患者的住院时间和住院总费用分别为(12.10±2.20)d和(26445.96±5553.78)元,明显少于对照组(P<0.05)。研究组治疗后 BNI 评分、PSQI、SAS/SDS 均低于对照组(P<0.05),但研究组面部麻木、口唇疱疹、咀嚼肌无力发生率高于对照组(P<0.05)。治疗后,研究组的 NLRP3 有所下降,与 BNI 评分呈正相关(P < .05)。此外,NLRP3 在预测复发方面也显示出很好的效果:结论:PBC能有效改善TN患者的疼痛和负面心理状态,而NLRP3与TN患者的疼痛密切相关。今后,PBC可用于临床治疗TN,改善患者的预后。
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来源期刊
Alternative therapies in health and medicine
Alternative therapies in health and medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
0.90
自引率
0.00%
发文量
219
期刊介绍: Launched in 1995, Alternative Therapies in Health and Medicine has a mission to promote the art and science of integrative medicine and a responsibility to improve public health. We strive to maintain the highest standards of ethical medical journalism independent of special interests that is timely, accurate, and a pleasure to read. We publish original, peer-reviewed scientific articles that provide health care providers with continuing education to promote health, prevent illness, and treat disease. Alternative Therapies in Health and Medicine was the first journal in this field to be indexed in the National Library of Medicine. In 2006, 2007, and 2008, ATHM had the highest impact factor ranking of any independently published peer-reviewed CAM journal in the United States—meaning that its research articles were cited more frequently than any other journal’s in the field. Alternative Therapies in Health and Medicine does not endorse any particular system or method but promotes the evaluation and appropriate use of all effective therapeutic approaches. Each issue contains a variety of disciplined inquiry methods, from case reports to original scientific research to systematic reviews. The editors encourage the integration of evidence-based emerging therapies with conventional medical practices by licensed health care providers in a way that promotes a comprehensive approach to health care that is focused on wellness, prevention, and healing. Alternative Therapies in Health and Medicine hopes to inform all licensed health care practitioners about developments in fields other than their own and to foster an ongoing debate about the scientific, clinical, historical, legal, political, and cultural issues that affect all of health care.
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