Recent Progress in Retinal Pigment Epithelium Cell-Based Therapy for Retinal Disease.

IF 5.4 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cells Translational Medicine Pub Date : 2024-04-15 DOI:10.1093/stcltm/szae004

Valeriia Klymenko, Orlando G González Martínez, Marco Zarbin

引用次数: 0

Abstract

Age-related macular degeneration and retinitis pigmentosa are degenerative retinal diseases that cause severe vision loss. Early clinical trials involving transplantation of retinal pigment epithelial cells and/or photoreceptors as a treatment for these conditions are underway. In this review, we summarize recent progress in the field of retinal pigment epithelium transplantation, including some pertinent clinical trial results as well as preclinical studies that address issues of transplant immunology, cell delivery, and cell manufacturing.

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视网膜色素上皮细胞治疗视网膜疾病的最新进展。

老年黄斑变性和视网膜色素变性是导致严重视力丧失的视网膜变性疾病。移植视网膜色素上皮细胞和/或光感受器来治疗这些疾病的早期临床试验正在进行中。在这篇综述中，我们总结了视网膜色素上皮细胞移植领域的最新进展，包括一些相关的临床试验结果，以及解决移植免疫学、细胞输送和细胞制造等问题的临床前研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cells Translational Medicine CELL & TISSUE ENGINEERING-

CiteScore

12.90

自引率

3.30%

发文量

140

审稿时长

6-12 weeks

期刊介绍： STEM CELLS Translational Medicine is a monthly, peer-reviewed, largely online, open access journal. STEM CELLS Translational Medicine works to advance the utilization of cells for clinical therapy. By bridging stem cell molecular and biological research and helping speed translations of emerging lab discoveries into clinical trials, STEM CELLS Translational Medicine will help move applications of these critical investigations closer to accepted best patient practices and ultimately improve outcomes. The journal encourages original research articles and concise reviews describing laboratory investigations of stem cells, including their characterization and manipulation, and the translation of their clinical aspects of from the bench to patient care. STEM CELLS Translational Medicine covers all aspects of translational cell studies, including bench research, first-in-human case studies, and relevant clinical trials.