Cognitive and brain connectivity trajectories in critically ill COVID-19 patients.

IF 1.7 4区医学 Q3 CLINICAL NEUROLOGY

NeuroRehabilitation Pub Date : 2024-01-01 DOI:10.3233/NRE-230216

Daniela Ramos-Usuga, Antonio Jimenez-Marin, Alberto Cabrera-Zubizarreta, Itziar Benito-Sanchez, Diego Rivera, Endika Martínez-Gutiérrez, Elena Panera, Victoria Boado, Fermín Labayen, Jesus M Cortes, Juan C Arango-Lasprilla

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引用次数: 0

Abstract

Background: Multiple Organ failure (MOF) is one of the main causes of admission to the Intensive Care Unit (ICU) of patients infected with COVID-19 and can cause short- and long-term neurological deficits.

Objective: To compare the cognitive functioning and functional brain connectivity at 6-12 months after discharge in two groups of individuals with MOF, one due to COVID-19 and the other due to another cause (MOF-group), with a group of Healthy Controls (HC).

Methods: Thirty-six participants, 12 from each group, underwent a neuropsychological and neuroimaging assessment at both time-points. Functional connectivity of the resting state networks was compared between COVID-19 and HC while controlling for the effect of MOF. The association between functional connectivity and neuropsychological performance was also investigated.

Results: Compared to the HC, COVID-19 group demonstrated hypoconnectivity between the Default Mode Network and Salience Network. This pattern was associated with worse performance on tests of attention and information processing speed, at both time-points.

Conclusion: The study of the association between cognitive function and brain functional connectivity in COVID-19 allows the understanding of the short- and long-term neurological alterations of this disease and promotes the development of intervention programs to improve the quality of life for this understudied population.

查看原文本刊更多论文

COVID-19 重症患者的认知和大脑连接轨迹。

背景：多器官功能衰竭（MOF）是感染 COVID-19 的患者入住重症监护病房（ICU）的主要原因之一，可导致短期和长期的神经功能缺损：目的：比较两组 MOF 患者（一组因 COVID-19 感染，另一组因其他原因感染（MOF 组））与一组健康对照组（HC）在出院后 6-12 个月的认知功能和大脑功能连接情况：方法：36 名参与者（每组 12 人）在两个时间点接受了神经心理学和神经影像学评估。在控制 MOF 影响的同时，比较了 COVID-19 和 HC 的静息态网络功能连接性。此外，还研究了功能连接性与神经心理学表现之间的关联：结果：与 HC 相比，COVID-19 组显示出默认模式网络和显著性网络之间的低连接性。这种模式与两个时间点的注意力和信息处理速度测试成绩较差有关：对COVID-19患者认知功能与大脑功能连接性之间关系的研究有助于了解这种疾病对神经系统造成的短期和长期改变，并促进干预方案的开发，以改善这一研究不足人群的生活质量。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroRehabilitation CLINICAL NEUROLOGY-REHABILITATION

CiteScore

3.20

自引率

0.00%

发文量

178

审稿时长

6-12 weeks

期刊介绍： NeuroRehabilitation, an international, interdisciplinary, peer-reviewed journal, publishes manuscripts focused on scientifically based, practical information relevant to all aspects of neurologic rehabilitation. We publish unsolicited papers detailing original work/research that covers the full life span and range of neurological disabilities including stroke, spinal cord injury, traumatic brain injury, neuromuscular disease and other neurological disorders. We also publish thematically organized issues that focus on specific clinical disorders, types of therapy and age groups. Proposals for thematic issues and suggestions for issue editors are welcomed.