The prognostic role of diet quality in patients with MAFLD and physical activity: data from NHANES.

IF 4.6 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Jiaofeng Huang, Yinlian Wu, Jiaping Zheng, Mingfang Wang, George Boon-Bee Goh, Su Lin
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Abstract

Background and objectives: Dietary control and increased physical activity (PA) are recommended for patients with metabolic (dysfunction-) associated fatty liver disease (MAFLD). However, not all patients can sustain both exercise and a healthy diet. This study explored the interaction between dietary quality, PA levels, and mortality in MAFLD patients.

Methods: The Third National Health and Nutrition Examination Survey and linked mortality data were used in this study. Diet quality was assessed with the Healthy Eating Index (HEI). PA level was calculated by multiply self-reported exercise frequency and its Metabolic Equivalent A high-quality diet was associated. A Cox proportional hazard model was used to explore risk factors for mortality in MAFLD patients.

Results: In total, 3709 participants with MAFLD were included in the final analysis. The median follow-up time was 26.2 (interquartile range 19.3-28.1) years and 1549 (41.8%) deaths were recorded over follow-up. Cox multivariate regression was used to adjust for potential confounders of mortality. The results showed both HEI score and PA level were inversely correlated with all-cause mortality (P < 0.05). In the subgroup analysis stratified by PA level, higher diet quality decreased all-cause mortality, cardiovascular-related mortality and cancer-related mortality in PA inactive of MAFLD patients (P < 0.05), but these correlations were not present in active PA groups.

Conclusion: Healthy diet and physical activity may have different impact as lifestyle interventions for MAFLD. A high-quality diet is associated less mortality in inactive individuals with MAFLD but not in those with active PA levels. Sedentary individuals require healthier diet.

Abstract Image

膳食质量对 MAFLD 患者的预后作用与体力活动:来自 NHANES 的数据。
背景和目的:建议代谢(功能障碍)相关性脂肪肝(MAFLD)患者控制饮食并增加体育锻炼(PA)。然而,并非所有患者都能同时坚持锻炼和健康饮食。本研究探讨了代谢(功能障碍)相关性脂肪肝患者的饮食质量、PA 水平和死亡率之间的相互作用:本研究采用了第三次全国健康与营养调查以及相关的死亡率数据。饮食质量通过健康饮食指数(HEI)进行评估。运动负荷水平通过自我报告的运动频率和其代谢当量相乘来计算。采用 Cox 比例危险模型探讨 MAFLD 患者的死亡风险因素:共有 3709 名 MAFLD 患者被纳入最终分析。随访时间中位数为 26.2 年(四分位数间距为 19.3-28.1 年),随访期间有 1549 人(41.8%)死亡。采用 Cox 多元回归法调整死亡率的潜在混杂因素。结果显示,HEI 评分和 PA 水平均与全因死亡率成反比(P 结论:HEI 评分和 PA 水平均与全因死亡率成反比:健康饮食和体育锻炼作为生活方式干预对 MAFLD 的影响可能不同。对于不运动的 MAFLD 患者来说,优质饮食可降低其死亡率,但对于积极参加体育锻炼的患者来说则不然。久坐不动的人需要更健康的饮食。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nutrition & Diabetes
Nutrition & Diabetes ENDOCRINOLOGY & METABOLISM-NUTRITION & DIETETICS
CiteScore
9.20
自引率
0.00%
发文量
50
审稿时长
>12 weeks
期刊介绍: Nutrition & Diabetes is a peer-reviewed, online, open access journal bringing to the fore outstanding research in the areas of nutrition and chronic disease, including diabetes, from the molecular to the population level.
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