Brusatol's anticancer activity and its molecular mechanism: a research update.

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of Pharmacy and Pharmacology Pub Date : 2024-07-05 DOI:10.1093/jpp/rgae017

Wenyi Xi, Chenhui Zhao, Zeyu Wu, Tongtong Ye, Rui Zhao, Xiaochun Jiang, Shizhang Ling

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引用次数: 0

Abstract

Objective: Brusatol (BT) is a quassinoid compound extracted from Brucea javanica that is a traditional Chinese herbal medicine. Brusatol possesses biological and medical activity, including antitumor, antileukemia, anti-inflammatory, antitrypanosomal, antimalarial, and antitobacco mosaic virus activity. To summarize and discuss the antitumor effects of BT and its mechanisms of actions, we compiled this review by combining the extensive relevant literature and our previous studies.

Methods: We searched and retrieved the papers that reported the pharmacological effects of BT and the mechanism of BT antitumor activity from PubMed until July 2023.

Key findings: Numerous studies have shown that BT is a unique nuclear factor erythroid 2-related factor 2 (Nrf2) inhibitor that acts on various signaling pathways and has good antitumor properties. Brusatol shows great potential in cancer therapy by inhibiting cell proliferation, blocking the cell cycle, promoting tumor cell differentiation, accelerating tumor cell apoptosis, inducing autophagy, suppressing angiogenesis, inhibiting tumor invasion and metastasis, and reversing multidrug resistance.

Conclusion: This review summarizes recent updates on the antitumor activity and molecular mechanisms of BT and provides references for future development and clinical translation of BT and its derivatives as antitumor drugs.

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Brusatol 的抗癌活性及其分子机制：最新研究进展。

目的Brusatol (BT) 是一种从传统中药材 Brucea javanica 中提取的槲皮苷化合物。Brusatol 具有生物和医学活性，包括抗肿瘤、抗白血病、抗炎、抗锥虫、抗疟和抗烟草花叶病毒等活性。为了总结和讨论 BT 的抗肿瘤作用及其作用机制，我们结合大量相关文献和以往的研究，编写了这篇综述：方法：我们从 PubMed 上搜索并检索了截至 2023 年 7 月报道 BT 药理作用及其抗肿瘤机制的论文：大量研究表明，BT是一种独特的核因子红细胞2相关因子2（Nrf2）抑制剂，可作用于多种信号通路，具有良好的抗肿瘤特性。Brusatol 通过抑制细胞增殖、阻断细胞周期、促进肿瘤细胞分化、加速肿瘤细胞凋亡、诱导自噬、抑制血管生成、抑制肿瘤侵袭和转移、逆转多药耐药性等作用，在癌症治疗中显示出巨大的潜力：本综述总结了 BT 抗肿瘤活性和分子机制的最新进展，为 BT 及其衍生物作为抗肿瘤药物的未来开发和临床转化提供了参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pharmacy and Pharmacology 医学-药学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： JPP keeps pace with new research on how drug action may be optimized by new technologies, and attention is given to understanding and improving drug interactions in the body. At the same time, the journal maintains its established and well-respected core strengths in areas such as pharmaceutics and drug delivery, experimental and clinical pharmacology, biopharmaceutics and drug disposition, and drugs from natural sources. JPP publishes at least one special issue on a topical theme each year.