A fibrin patch loaded with mesenchymal stem cells-derived exosomes improves cardiac functions after myocardial infarction

IF 4.7 3区材料科学 Q2 CHEMISTRY, PHYSICAL

Colloid and Interface Science Communications Pub Date : 2024-02-23 DOI:10.1016/j.colcom.2024.100775

Xiaoyu Wang , Jingjing Wang , Yanxia Zhang , Yunsheng Yu , Zhenya Shen

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Abstract

Myocardial infarction (MI) is a typical cardiovascular disease, causing disability and death worldwide. Exosomes secreted by mesenchymal stem cells (MSCs) showed remarkable therapeutic effects in MI by restoring cardiac function. However, the application of exosomes remains a challenge because of their low residence rate in the infarcted myocardium. Herein, a fibrin-based cardiac patch was prepared to deliver MSCs-derived exosomes to the infarcted heart using an MI mouse model, aiming at improvement of cardiac functions. The fibrin patch was optimized for size to minimize the mouse mortality rate. The composite patch showed sustained release of exosomes in vitro and could improve the retention of exosomes in the infarcted heart, inhibiting fibrosis and improving cardiac functions in vivo. Therefore, this combination of natural biomaterial-based cardiac patch and MSCs-derived exosomes may have a promising clinical translational potential for the MI treatment.

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含有间充质干细胞外泌体的纤维蛋白贴片可改善心肌梗死后的心脏功能

心肌梗塞（MI）是一种典型的心血管疾病，在全球范围内造成残疾和死亡。间充质干细胞（MSCs）分泌的外泌体对心肌梗死有显著的治疗效果，能恢复心脏功能。然而，由于外泌体在梗死心肌中的停留率较低，其应用仍是一项挑战。在此，我们制备了一种基于纤维蛋白的心脏补片，利用心肌梗死小鼠模型将间叶干细胞衍生的外泌体输送到梗死的心脏，从而改善心脏功能。对纤维蛋白补片的尺寸进行了优化，以最大限度地降低小鼠死亡率。复合贴片在体外显示出外泌体的持续释放，并能改善外泌体在梗死心脏中的滞留，从而抑制纤维化并改善体内心脏功能。因此，这种基于天然生物材料的心脏贴片与间充质干细胞衍生的外泌体的结合可能在心肌梗死治疗方面具有良好的临床转化潜力。

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来源期刊

Colloid and Interface Science Communications Materials Science-Materials Chemistry

CiteScore

9.40

自引率

6.70%

发文量

125

审稿时长

43 days

期刊介绍： Colloid and Interface Science Communications provides a forum for the highest visibility and rapid publication of short initial reports on new fundamental concepts, research findings, and topical applications at the forefront of the increasingly interdisciplinary area of colloid and interface science.