Visual associative learning to detect early episodic memory deficits and distinguish Alzheimer's disease from other types of dementia.

IF 2.6 4区 心理学 Q2 CLINICAL NEUROLOGY
Mark A Dubbelman, Jori Tomassen, Sophie M van der Landen, Els Bakker, Suzie Kamps, Annemartijn A J M van Unnik, Marie-Christine A B J van de Glind, Annelies E van der Vlies, Ted Koene, Anna E Leeuwis, Frederik Barkhof, Argonde C van Harten, Charlotte Teunissen, Elsmarieke van de Giessen, Afina W Lemstra, Yolande A L Pijnenburg, Rudolf W H Ponds, Sietske A M Sikkes
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引用次数: 0

Abstract

Objective: We investigated how well a visual associative learning task discriminates Alzheimer's disease (AD) dementia from other types of dementia and how it relates to AD pathology.

Methods: 3,599 patients (63.9 ± 8.9 years old, 41% female) from the Amsterdam Dementia Cohort completed two sets of the Visual Association Test (VAT) in a single test session and underwent magnetic resonance imaging. We performed receiver operating curve analysis to investigate the VAT's discriminatory ability between AD dementia and other diagnoses and compared it to that of other episodic memory tests. We tested associations between VAT performance and medial temporal lobe atrophy (MTA), and amyloid status (n = 2,769, 77%).

Results: Patients with AD dementia performed worse on the VAT than all other patients. The VAT discriminated well between AD and other types of dementia (area under the curve range 0.70-0.86), better than other episodic memory tests. Six-hundred forty patients (17.8%) learned all associations on VAT-A, but not on VAT-B, and they were more likely to have higher MTA scores (odds ratios range 1.63 (MTA 0.5) through 5.13 for MTA ≥ 3, all p < .001) and to be amyloid positive (odds ratio = 3.38, 95%CI = [2.71, 4.22], p < .001) than patients who learned all associations on both sets.

Conclusions: Performance on the VAT, especially on a second set administered immediately after the first, discriminates AD from other types of dementia and is associated with MTA and amyloid positivity. The VAT might be a useful, simple tool to assess early episodic memory deficits in the presence of AD pathology.

通过视觉联想学习检测早期外显记忆缺陷,区分阿尔茨海默病和其他类型的痴呆症。
目的方法:来自阿姆斯特丹痴呆队列的3599名患者(63.9 ± 8.9岁,41%为女性)在一次测试中完成了两组视觉联想测试(VAT),并接受了磁共振成像检查。我们对 VAT 进行了接收器操作曲线分析,以研究它在阿德痴呆症和其他诊断之间的区分能力,并将其与其他外显记忆测试进行了比较。我们测试了VAT表现与内侧颞叶萎缩(MTA)和淀粉样蛋白状态(n = 2,769, 77%)之间的关联:结果:AD痴呆症患者的VAT表现比其他所有患者都差。VAT能很好地区分AD痴呆和其他类型的痴呆(曲线下面积范围为0.70-0.86),优于其他外显记忆测试。六百四十名患者(17.8%)学会了VAT-A的所有联想,但没有学会VAT-B,与学会两组所有联想的患者相比,他们更有可能获得更高的MTA评分(几率比范围为1.63(MTA 0.5)至5.13(MTA≥3),所有P < .001)和淀粉样蛋白阳性(几率比=3.38,95%CI = [2.71,4.22],P < .001):VAT测试的成绩,尤其是在第一套测试后立即进行的第二套测试的成绩,可以区分AD和其他类型的痴呆,并且与MTA和淀粉样蛋白阳性相关。VAT可能是一种有用、简单的工具,可用于评估存在AD病变的早期外显记忆缺陷。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.40
自引率
3.80%
发文量
185
审稿时长
4-8 weeks
期刊介绍: The Journal of the International Neuropsychological Society is the official journal of the International Neuropsychological Society, an organization of over 4,500 international members from a variety of disciplines. The Journal of the International Neuropsychological Society welcomes original, creative, high quality research papers covering all areas of neuropsychology. The focus of articles may be primarily experimental, applied, or clinical. Contributions will broadly reflect the interest of all areas of neuropsychology, including but not limited to: development of cognitive processes, brain-behavior relationships, adult and pediatric neuropsychology, neurobehavioral syndromes (such as aphasia or apraxia), and the interfaces of neuropsychology with related areas such as behavioral neurology, neuropsychiatry, genetics, and cognitive neuroscience. Papers that utilize behavioral, neuroimaging, and electrophysiological measures are appropriate. To assure maximum flexibility and to promote diverse mechanisms of scholarly communication, the following formats are available in addition to a Regular Research Article: Brief Communication is a shorter research article; Rapid Communication is intended for "fast breaking" new work that does not yet justify a full length article and is placed on a fast review track; Case Report is a theoretically important and unique case study; Critical Review and Short Review are thoughtful considerations of topics of importance to neuropsychology and include meta-analyses; Dialogue provides a forum for publishing two distinct positions on controversial issues in a point-counterpoint format; Special Issue and Special Section consist of several articles linked thematically; Letter to the Editor responds to recent articles published in the Journal of the International Neuropsychological Society; and Book Review, which is considered but is no longer solicited.
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