Implicaciones de la arginina-vasopresina y de la copeptina en la gestación normal y en la preeclampsia

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.1016/j.hipert.2023.08.002

M. Heras Benito

引用次数: 0

Abstract

Preeclampsia represents a specific complication of pregnancy hypertension, which appears de novo after the 20th week of gestation, accompanied by proteinuria and/or maternal or utero-placental organ dysfunction. Despite an uncertain etiopathogenesis, impaired vascular remodeling of the spiral artery and placental ischemia is the most widespread hypothesis. The finding of elevated levels of copeptin in women with preeclampsia compared to normal pregnant women has valued the involvement of arginine vasopressin in the etiopathogenesis of this complication. In this paper, its usefulness as a marker of preeclampsia is considered through the review of the main studies carried out with this molecule.

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[精氨酸-血管加压素和 copeptin 对正常妊娠和子痫前期的影响]。

子痫前期是妊娠高血压的一种特殊并发症，在妊娠 20 周后新出现，伴有蛋白尿和/或母体或子宫胎盘器官功能障碍。尽管发病机制不确定，但螺旋动脉血管重塑受损和胎盘缺血是最普遍的假设。与正常孕妇相比，发现子痫前期妇女体内的 copeptin 水平升高，这说明精氨酸加压素参与了这一并发症的发病机制。本文通过回顾对该分子进行的主要研究，探讨其作为子痫前期标志物的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.