Bright Light Therapy for Major Depressive Disorder in Adolescent Outpatients: A Preliminary Study.

IF 2.1 Q3 CLINICAL NEUROLOGY
Rachel Ballard, John T Parkhurst, Lisa K Gadek, Kelsey M Julian, Amy Yang, Lauren N Pasetes, Namni Goel, Dorothy K Sit
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Abstract

Background: Bright light therapy (BLT) has not been well-studied in adolescents with major depressive disorder, particularly in outpatient settings.

Methods: We conducted an 8-week clinical trial of BLT in adolescents recruited from a primary care practice with moderate to severe major depression. Acceptability and feasibility were defined by daily use of the light box and integration into daily routines. To assess treatment effects, we utilized the Short Mood and Feelings Questionnaire (SMFQ) and actigraphic sleep variables.

Results: Of the nine enrolled adolescents, the rate of daily use of the light therapy box was 100% at week 2, 78% at week 4 (n = 7), and 67% at weeks 6 and 8 (n = 6). Participants were better able to integrate midday BLT compared to morning BLT into their day-to-day routines. Mean depression scores improved during the 2-week placebo lead-in (dim red light-DRL) and continued to show significant improvement through 6 weeks of BLT. Sleep efficiency increased significantly (p = 0.046), and sleep onset latency showed a trend toward a significant decrease (p = 0.075) in the BLT phase compared to the DRL phase.

Conclusion: Bright light treatment that was self-administered at home was feasible, acceptable, and effective for adolescent outpatients with depression. Findings support the development of larger, well-powered, controlled clinical trials of BLT in coordination with primary care.

亮光疗法治疗青少年门诊患者的重度抑郁症:初步研究。
背景:亮光疗法(BLT)在患有重度抑郁症的青少年中尚未得到充分研究,尤其是在门诊环境中:我们对从初级保健诊所招募的患有中度至重度重度抑郁症的青少年进行了为期 8 周的亮光疗法临床试验。可接受性和可行性由灯箱的日常使用和与日常生活的结合来定义。为了评估治疗效果,我们使用了简短情绪和感觉问卷(SMFQ)以及行为记录睡眠变量:结果:在 9 名参加治疗的青少年中,第 2 周每天使用光疗箱的比例为 100%,第 4 周为 78%(7 人),第 6 周和第 8 周为 67%(6 人)。与早上使用光疗箱相比,参与者能更好地将中午光疗箱融入日常作息中。在为期 2 周的安慰剂引导期(昏暗红光-DRL)中,平均抑郁评分有所改善,在 BLT 6 周后仍有显著改善。睡眠效率明显提高(p = 0.046),与DRL阶段相比,BLT阶段的睡眠开始潜伏期呈明显下降趋势(p = 0.075):结论:对门诊青少年抑郁症患者来说,在家中自行进行的强光治疗是可行的、可接受的、有效的。研究结果支持在基层医疗机构的配合下,开展更大规模的、有充分证据支持的BLT临床对照试验。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Clocks & Sleep
Clocks & Sleep Multiple-
CiteScore
4.40
自引率
0.00%
发文量
0
审稿时长
7 weeks
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