Angelica keiskei water extract Mitigates Age-Associated Physiological Decline in Mice.

IF 5.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Redox Report Pub Date : 2024-12-01 Epub Date: 2024-02-23 DOI:10.1080/13510002.2024.2305036

Huan Liu, Gang Wei, Tongxing Wang, Yunlong Hou, Bin Hou, Xiaoyan Li, Chao Wang, Mingzhe Sun, Min Su, Zhifang Guo, Lu Wang, Ning Kang, Mengnan Li, Zhenhua Jia

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引用次数: 0

Abstract

Objective: Angelica keiskei is a medicinal and edible plant that has been reported to possess potent antioxidant properties in several in vitro models, but its effectiveness on naturally aging organisms is still lacking. This study explores the antioxidant and health-promoting effects of Angelica keiskei in naturally aging mice.

Methods: We treated 48-week-old mice with Angelica keiskei water extract (AKWE) 30 days, and measured indicators related to aging and antioxidants. In addition, we conducted network pharmacology analysis, component-target molecular docking, real-time PCR, and MTS assays to investigate relevant factors.

Results: The results indicated that administration of AKWE to mice led to decrease blood glucose levels, improve muscle fiber structure, muscle strength, gait stability, and increase levels of glutathione and superoxide dismutase in serum. Additionally, it decreased pigmentation of the heart tissues. Angelica keiskei combats oxidative stress by regulating multiple redox signaling pathways, and its ingredients Coumarin and Flavonoids have the potential to bind to SIRT3 and SIRT5.

Conclusions: Our findings indicated the potential of Angelica keiskei as a safe and effective dietary supplement to combat aging and revealed the broad prospects of medicinal and edible plants for addressing aging and age-related chronic diseases.

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当归水提取物能缓解小鼠与年龄相关的生理机能衰退

目的：当归是一种药用和食用植物，有报道称它在多个体外模型中具有强大的抗氧化特性，但其对自然衰老生物的有效性仍然缺乏研究。本研究探讨了当归对自然衰老小鼠的抗氧化和促进健康作用：方法：我们用当归水提取物（AKWE）治疗48周龄的小鼠30天，并测量与衰老和抗氧化剂相关的指标。此外，我们还进行了网络药理学分析、成分-靶标分子对接、实时 PCR 和 MTS 检测，以研究相关因素：结果表明，给小鼠服用 AKWE 能降低血糖水平，改善肌纤维结构、肌力和步态稳定性，提高血清中谷胱甘肽和超氧化物歧化酶的水平。此外，它还能减少心脏组织的色素沉着。当归通过调节多种氧化还原信号通路来对抗氧化应激，其成分香豆素和黄酮类化合物有可能与 SIRT3 和 SIRT5 结合：我们的研究结果表明了当归作为一种安全有效的抗衰老膳食补充剂的潜力，并揭示了药用和食用植物在应对衰老和与年龄相关的慢性疾病方面的广阔前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Redox Report 生物-生化与分子生物学

CiteScore

6.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Redox Report is a multidisciplinary peer-reviewed open access journal focusing on the role of free radicals, oxidative stress, activated oxygen, perioxidative and redox processes, primarily in the human environment and human pathology. Relevant papers on the animal and plant environment, biology and pathology will also be included. While emphasis is placed upon methodological and intellectual advances underpinned by new data, the journal offers scope for review, hypotheses, critiques and other forms of discussion.