Patients with infusion-related reactions on fixed-dose rituximab treatment have higher body surface area than those without infusion-related reactions in adults with frequently relapsing minimal change nephrotic syndrome: a retrospective study.

IF 1.2 Q4 PHARMACOLOGY & PHARMACY
Hironobu Nishiura, Masaya Takahashi, Katsuhito Mori, Takashi Sugimoto, Masanori Emoto, Yasutaka Nakamura
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引用次数: 0

Abstract

Background: Infusion-related reactions (IRRs) are major side effects of rituximab administration. Male sex, high body weight, body surface area (BSA), and body mass index are predictive markers of rituximab-induced IRRs. However, as rituximab was not administered at a fixed dosage in a previous study, whether a higher dosage or factors associated with a larger physique are more strongly associated with rituximab-induced IRRs is unknown.

Main body: Thirteen adults with frequently relapsing minimal change nephrotic syndrome (MCNS) who received an initial rituximab dose of 500 mg between September 2015 and November 2022 were retrospectively evaluated. Data on IRRs were collected from medical records. The incidence of rituximab-induced IRRs was 38.5% (5/13). The IRR group had a significantly higher BSA than the non-IRR group (median, 1.86 vs. 1.48 m2; p = 0.045). Additionally, rituximab dosage normalized by BSA in the IRR group was significantly lower than that in the non-IRR group (median, 268.8 vs. 337.9 mg/m2; p = 0.045).

Conclusions: Our study revealed that adults with frequently relapsing MCNS who experienced IRRs tend to have a higher BSA, even with fixed-dose rituximab treatment. Therefore, when patients with higher BSA receive rituximab treatment, clinicians should be careful about monitoring patient condition whether the dosage is fixed or not.

一项回顾性研究:在经常复发的微小病变肾病综合征成人患者中,接受固定剂量利妥昔单抗治疗后出现输液相关反应的患者的体表面积高于未出现输液相关反应的患者。
背景输液相关反应(IRR)是利妥昔单抗用药的主要副作用。男性、高体重、体表面积(BSA)和体重指数是利妥昔单抗引起输液相关反应的预测指标。然而,由于在之前的一项研究中,利妥昔单抗的用药剂量并不固定,因此,用药剂量越大或体型越大的相关因素是否与利妥昔单抗诱发的IRR有更强的关联尚不清楚:对2015年9月至2022年11月期间接受初始剂量为500毫克利妥昔单抗治疗的13名经常复发的肾病综合征(MCNS)成人患者进行了回顾性评估。IRR数据来自医疗记录。利妥昔单抗引起的IRR发生率为38.5%(5/13)。IRR组的BSA明显高于非IRR组(中位数为1.86平方米对1.48平方米;P = 0.045)。此外,IRR组的利妥昔单抗剂量按BSA归一化后明显低于非IRR组(中位数,268.8 vs. 337.9 mg/m2; p = 0.045):我们的研究显示,频繁复发的成人 MCNS 患者在经历 IRR 后,即使接受固定剂量利妥昔单抗治疗,其 BSA 也往往较高。因此,当 BSA 较高的患者接受利妥昔单抗治疗时,无论剂量是否固定,临床医生都应注意监测患者的病情。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
29
审稿时长
8 weeks
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