Methylphenidate and Sleep Difficulties in Children and Adolescents With ADHD: Results From the 2-Year Naturalistic Pharmacovigilance ADDUCE Study.

IF 2.7 3区医学 Q2 PSYCHIATRY

Journal of Attention Disorders Pub Date : 2024-03-01 Epub Date: 2024-02-22 DOI:10.1177/10870547241232337

Alexander Häge, Kenneth K C Man, Sarah K Inglis, Jan Buitelaar, Sara Carucci, Marina Danckaerts, Ralf W Dittmann, Bruno Falissard, Peter Garas, Chris Hollis, Kerstin Konrad, Hanna Kovshoff, Elizabeth Liddle, Suzanne McCarthy, Antje Neubert, Peter Nagy, Eric Rosenthal, Edmund J S Sonuga-Barke, Alessandro Zuddas, Ian C K Wong, David Coghill, Tobias Banaschewski

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引用次数: 0

Abstract

Objective: Short-term RCTs have demonstrated that MPH-treatment significantly reduces ADHD-symptoms, but is also associated with adverse events, including sleep problems. However, data on long-term effects of MPH on sleep remain limited.

Methods: We performed a 2-year naturalistic prospective pharmacovigilance multicentre study. Participants were recruited into three groups: ADHD patients intending to start MPH-treatment (MPH-group), those not intending to use ADHD-medication (no-MPH-group), and a non-ADHD control-group. Sleep problems were assessed with the Children's-Sleep-Habits-Questionnaire (CSHQ).

Results: 1,410 participants were enrolled. Baseline mean CSHQ-total-sleep-scores could be considered clinically significant for the MPH-group and the no-MPH-group, but not for controls. The only group to show a significant increase in any aspect of sleep from baseline to 24-months was the control-group. Comparing the MPH- to the no-MPH-group no differences in total-sleep-score changes were found.

Conclusion: Our findings support that sleep-problems are common in ADHD, but don't suggest significant negative long-term effects of MPH on sleep.

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哌醋甲酯与多动症儿童和青少年的睡眠障碍：为期两年的自然药物警戒 ADDUCE 研究结果。

目的：短期 RCT 研究表明，MPH 治疗能显著减轻多动症症状，但也会带来不良反应，包括睡眠问题。然而，有关 MPH 对睡眠的长期影响的数据仍然有限：我们进行了一项为期两年的自然前瞻性药物警戒多中心研究。参与者分为三组：方法：我们进行了一项为期两年的自然前瞻性多中心药物警戒研究，将参与者分为三组：打算开始接受 MPH 治疗的多动症患者（MPH 组）、不打算使用多动症药物的患者（无 MPH 组）以及非多动症对照组。睡眠问题通过儿童睡眠习惯问卷（CSHQ）进行评估：结果：共有 1,410 人参加。多动症组和非多动症组的 CSHQ 总睡眠分数基线平均值具有临床意义，而对照组则没有。从基线到 24 个月期间，只有对照组在睡眠的任何方面出现了显著增长。将MPH组与无MPH组进行比较，没有发现总睡眠分数变化的差异：我们的研究结果表明，睡眠问题在多动症患者中很常见，但并不表明 MPH 对睡眠有明显的长期负面影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Attention Disorders PSYCHIATRY-

CiteScore

7.60

自引率

6.70%

发文量

审稿时长

6-12 weeks

期刊介绍： Journal of Attention Disorders (JAD) focuses on basic and applied science concerning attention and related functions in children, adolescents, and adults. JAD publishes articles on diagnosis, comorbidity, neuropsychological functioning, psychopharmacology, and psychosocial issues. The journal also addresses practice, policy, and theory, as well as review articles, commentaries, in-depth analyses, empirical research articles, and case presentations or program evaluations.