The interaction between magnesium intake, the genetic variant INSR rs1799817 and colorectal cancer risk in a Korean population: a case-control study.

IF 3.5 2区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

International Journal of Food Sciences and Nutrition Pub Date : 2024-06-01 Epub Date: 2024-02-22 DOI:10.1080/09637486.2024.2314678

Linh Thi Dieu Nguyen, Madhawa Gunathilake, Jeonghee Lee, Jae Hwan Oh, Hee Jin Chang, Dae Kyung Sohn, Aesun Shin, Jeongseon Kim

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引用次数: 0

Abstract

Magnesium may have a significant impact on the development of cancer. However, the relationship between magnesium intake and the risk of colorectal cancer (CRC) is unclear. Therefore, we evaluated the association between magnesium intake and the risk of CRC, and we investigated how the insulin receptor (INSR) rs1799817 variant impacts this relationship. Data from 1,420 CRC patients and 2,840 controls from the Korean National Cancer Centre were analysed. A higher intake of magnesium was associated with a reduced risk of CRC in the total population (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.52-0.81). We found that G + carriers of INSR rs1799817 with higher magnesium intake had a significantly lower risk of CRC (p _{for interaction} = 0.003). Our findings indicated that high magnesium intake could be associated with a decreased risk of CRC, and this association could be modified by the INSR rs1799817 variant.

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韩国人群镁摄入量、INSR rs1799817 基因变异与结直肠癌风险之间的相互作用：一项病例对照研究。

镁可能对癌症的发生有重大影响。然而，镁摄入量与结直肠癌（CRC）风险之间的关系尚不清楚。因此，我们评估了镁摄入量与 CRC 风险之间的关系，并研究了胰岛素受体（INSR）rs1799817 变体如何影响这种关系。我们分析了来自韩国国立癌症中心的 1,420 名 CRC 患者和 2,840 名对照者的数据。在所有人群中，镁摄入量越高，患 CRC 的风险越低（几率比（OR）= 0.65，95% 置信区间（CI）= 0.52-0.81）。我们发现，镁摄入量较高的 INSR rs1799817 G + 携带者患 CRC 的风险显著降低（交互作用 p = 0.003）。我们的研究结果表明，镁的高摄入量可降低患 CRC 的风险，而 INSR rs1799817 变异可改变这种关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Food Sciences and Nutrition 工程技术-食品科技

CiteScore

7.50

自引率

2.60%

发文量

审稿时长

1 months

期刊介绍： The primary aim of International Journal of Food Sciences and Nutrition is to integrate food science with nutrition. Improvement of knowledge in human nutrition should always be the final objective of submitted research. It''s an international, peer-reviewed journal which publishes high quality, original research contributions to scientific knowledge. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.