Influence of Cytokine Genetic Polymorphisms in Helicobacter pylori-Associated Gastric Inflammation According to Sex in South Korea.

IF 3.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Gut and Liver Pub Date : 2024-11-15 Epub Date: 2024-02-23 DOI:10.5009/gnl230359

Hee Jin Kim, Nayoung Kim, Jae Young Jang, Sihyun Kim, Jongchan Lee, Hyeon Jeong Oh

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引用次数: 0

Abstract

Background/aims: : The relationship between genetic polymorphisms and gastric inflammation remains unclear. This study aimed to evaluate the impact of genetic polymorphisms on Helicobacter pylori (HP)-associated gastritis according to sex.

Methods: : Two hundred thirty-two male and 404 female subjects with current HP infection were prospectively enrolled. The genotyping of IL-1B-511 C/T, IL-1RN variable number of tandem repeats, IL-6-572 G/C, IL-8-251 A/T, IL-8-781 C/T, IL-10-1082 G/A, IL-10-592 C/A, TNF-A-308 G/A, and transforming growth factor (TGF)-B-509 C/T, was determined by polymerase chain reaction-restriction fragment length polymorphism. The degree of monocyte or neutrophil infiltration, atrophic gastritis, and intestinal metaplasia was evaluated using the updated Sydney system.

Results: : Among the male subjects, moderate/severe atrophic gastritis of the corpus was higher in IL-1B-511 CC carriers than in CT and TT carriers independent of age, alcohol consumption, and HP virulence factors (26.9% vs 10.4%; adjusted hazard ratio [HR], 4.377; 95% confidence interval, 1.387 to 13.814). In females, IL-8-251 AA carriers were independently and significantly associated with moderate/severe atrophic gastritis of the corpus compared with that in AT and TT carriers (21.4% vs 6.0%, adjusted HR=3.799). In males, the IL-8-251 TT genotype was associated with moderate/severe intestinal metaplasia of the corpus compared with the AT and AA genotypes (13.4% vs 5.6%, adjusted HR=3.128), while the IL-10-592 CA and CC genotypes were associated with moderate/severe monocyte infiltration of the antrum compared with AA genotype (83.6% vs 71.8%, adjusted HR=2.227).

Conclusions: : Genetic polymorphisms in cytokines play different roles in HP-associated gastritis according to sex.

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韩国不同性别的细胞因子基因多态性对幽门螺杆菌相关性胃炎的影响

背景/目的：：基因多态性与胃炎之间的关系仍不清楚。本研究旨在评估不同性别的基因多态性对幽门螺杆菌（HP）相关性胃炎的影响：方法：前瞻性地招募了 232 名男性和 404 名女性幽门螺杆菌感染者。通过聚合酶链式反应-限制性片段长度多态性测定了IL-1B-511 C/T、IL-1RN可变串联重复序列、IL-6-572 G/C、IL-8-251 A/T、IL-8-781 C/T、IL-10-1082 G/A、IL-10-592 C/A、TNF-A-308 G/A和转化生长因子（TGF）-B-509 C/T的基因型。采用最新的悉尼系统对单核细胞或中性粒细胞浸润、萎缩性胃炎和肠化生的程度进行了评估：在男性受试者中，IL-1B-511 CC携带者的中度/重度萎缩性胃炎高于CT和TT携带者（26.9% vs 10.4%；调整后危险比[HR]为4.377；95%置信区间为1.387至13.814），与年龄、饮酒量和HP致病因素无关。在女性中，与AT和TT携带者相比，IL-8-251 AA携带者与中度/重度萎缩性胃炎（21.4% vs 6.0%，调整后危险比=3.799）有显著的相关性。在男性中，与 AT 和 AA 基因型相比，IL-8-251 TT 基因型与胃体中度/重度肠化生相关（13.4% vs 5.6%，调整后 HR=3.128），而与 AA 基因型相比，IL-10-592 CA 和 CC 基因型与胃窦中度/重度单核细胞浸润相关（83.6% vs 71.8%，调整后 HR=2.227）：细胞因子的基因多态性在HP相关性胃炎中的作用因性别而异。

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来源期刊

Gut and Liver 医学-胃肠肝病学

CiteScore

7.50

自引率

8.80%

发文量

119

审稿时长

6-12 weeks

期刊介绍： Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.