Daily Diet and Nutrition Risk Factors for Gastric Cancer Incidence in a Japanese Population.

IF 3.4 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Gut and Liver Pub Date : 2024-07-15 Epub Date: 2024-02-23 DOI:10.5009/gnl230354

Ayaka Takasu, Takuji Gotoda, Sho Suzuki, Chika Kusano, Chiho Goto, Hideki Ishikawa, Hirofumi Kogure

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引用次数: 0

Abstract

Background/aims: : Nutritional factors associated with gastric cancer (GC) are not completely understood. We aimed to determine the effect of nutrient intake on the incidence of GC.

Methods: : This was a post hoc analysis of a prospective trial that evaluated modalities for GC screening in participants aged 30 to 74 years living in high-risk areas for GC in Japan between June 2011 and March 2013. The patients were followed up for GC incidence for 6 years. All participants completed a self-administered food frequency questionnaire (FFQ) upon enrollment before GC screening. Daily nutrient intake was calculated from the FFQ and dichotomized at each cutoff value using receiver operating characteristic analysis. Risk factors associated with GC incidence were investigated in terms of nutrient intake and participant characteristics using Cox proportional hazards regression analysis.

Results: : Overall, 1,147 participants were included in this analysis. The median age was 62 years, and 50.7% of the participants were men. The median follow-up period was 2,184 days. GC was detected in 25 participants during the follow-up. Multivariate Cox proportional hazards regression analysis revealed that the intake of sodium (adjusted hazards ratio [aHR], 3.905; 95% confidence interval [CI], 1.520 to 10.035; p=0.005) and vitamin D (aHR, 2.747; 95% CI, 1.111 to 6.788, p=0.029) were positively associated with GC incidence, whereas the intake of soluble dietary fiber (aHR, 0.104; 95% CI, 0.012 to 0.905; p=0.040) was inversely associated with GC incidence.

Conclusions: : Daily high intake of sodium and vitamin D and low soluble dietary fiber intake are associated with GC incidence.

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日本人口胃癌发病率的日常饮食和营养风险因素。

背景/目的：：与胃癌（GC）相关的营养因素尚不完全清楚。我们旨在确定营养摄入对胃癌发病率的影响：这是一项前瞻性试验的事后分析，该试验评估了 2011 年 6 月至 2013 年 3 月期间日本胃癌高风险地区 30 至 74 岁人群的胃癌筛查方式。对这些患者的 GC 发病率进行了为期 6 年的随访。所有参与者在接受 GC 筛查前都填写了一份自填式食物频率问卷 (FFQ)。根据 FFQ 计算出每日营养素摄入量，并使用接收器操作特征分析法对每个临界值进行二分。利用考克斯比例危险回归分析法，从营养素摄入量和参与者特征的角度研究了与胃癌发病率相关的风险因素：共有 1,147 名参与者参与了此次分析。中位年龄为 62 岁，50.7% 的参与者为男性。随访时间中位数为 2,184 天。在随访期间，有 25 名参与者检测出 GC。多变量考克斯比例危险回归分析显示，钠摄入量（调整危险比 [aHR]，3.905；95% 置信区间 [CI]，1.520 至 10.035；p=0.005）和维生素 D 摄入量（aHR，2.747；95% 置信区间 [CI]，1.111至6.788，p=0.029）与GC发病率呈正相关，而可溶性膳食纤维的摄入量（aHR，0.104；95% CI，0.012至0.905；p=0.040）与GC发病率呈反相关：结论：每日钠和维生素 D 的高摄入量以及可溶性膳食纤维的低摄入量与 GC 发病率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gut and Liver 医学-胃肠肝病学

CiteScore

7.50

自引率

8.80%

发文量

119

审稿时长

6-12 weeks

期刊介绍： Gut and Liver is an international journal of gastroenterology, focusing on the gastrointestinal tract, liver, biliary tree, pancreas, motility, and neurogastroenterology. Gut and Liver delivers up-to-date, authoritative papers on both clinical and research-based topics in gastroenterology. The Journal publishes original articles, case reports, brief communications, letters to the editor and invited review articles in the field of gastroenterology. The Journal is operated by internationally renowned editorial boards and designed to provide a global opportunity to promote academic developments in the field of gastroenterology and hepatology. Gut and Liver is jointly owned and operated by 8 affiliated societies in the field of gastroenterology, namely: the Korean Society of Gastroenterology, the Korean Society of Gastrointestinal Endoscopy, the Korean Society of Neurogastroenterology and Motility, the Korean College of Helicobacter and Upper Gastrointestinal Research, the Korean Association for the Study of Intestinal Diseases, the Korean Association for the Study of the Liver, the Korean Pancreatobiliary Association, and the Korean Society of Gastrointestinal Cancer.