Development of Deep Eutectic Solvent Based Ferrofluid Liquid Phase Microextraction for the Determination of Ofloxacin in Egg and Milk Samples

IF 2.6 3区农林科学 Q2 FOOD SCIENCE & TECHNOLOGY

Food Analytical Methods Pub Date : 2024-02-19 DOI:10.1007/s12161-024-02593-x

Siti Suraiya Samsudin, Rania Edrees Adam Mohammad, Noorfatimah Yahaya, Mazidatulakmam Miskam

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Abstract

A smart material based on ferrofluid deep eutectic solvents graphene oxide magnetite (MGO-DES FF) was successfully synthesized by adding choline chloride-thymol DES as carrier solvent onto MGO composite for the determination of ofloxacin in egg and milk samples. The synthesized materials were characterized using Fourier transform-infrared spectroscopy (FTIR), transmission electron microscopy (TEM), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and vibration sample magnetometer (VSM) to evaluate their functional groups, morphological and magnetic properties, respectively. The MGO-DES FF material was used as ferrofluid sorbent for liquid phase microextraction (LPME) of ofloxacin prior to UV–Vis spectrophotometry analysis. Several parameters were optimized including the type of DES, ferrofluid composition, ferrofluid volume, desorption solvent type and volume, pH, and extraction time to study their effects on the recovery percentage of ofloxacin. Under optimum conditions, good linearity was achieved between the range of 1 – 10 mg L⁻¹ for ofloxacin and a correlation coefficient of 0.9963. The LOD and LOQ values recorded were 0.75 and 1.55 µg L⁻¹, respectively. The RSD% for intra-day and inter-day were 2.64 and 7.40, respectively. The recovery percentage for milk and egg samples was ranging from 80.8 to 92.0%. Based on the results obtained, the developed MGO-DES FF LPME method demonstrated excellent sensitivity and efficiency for the extraction of ofloxacin in food samples. It showed great potential as an alternative method for the extraction of pharmaceutically active contaminants in the challenging matrix.

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开发基于深共晶溶剂的铁流体液相微萃取技术，用于测定鸡蛋和牛奶样品中的氧氟沙星

通过在 MGO 复合材料中加入氯化胆碱-百里酚 DES 作为载体溶剂，成功合成了一种基于铁流体深共晶溶剂氧化石墨烯磁铁矿的智能材料（MGO-DES FF），用于测定鸡蛋和牛奶样品中的氧氟沙星。利用傅立叶变换红外光谱（FTIR）、透射电子显微镜（TEM）、扫描电子显微镜（SEM）、热重分析（TGA）和振动样品磁力计（VSM）分别对合成材料的官能团、形貌和磁性进行了表征。MGO-DES FF 材料被用作铁流体吸附剂，用于氧氟沙星的液相微萃取（LPME），然后进行紫外可见分光光度法分析。对多个参数进行了优化，包括 DES 类型、铁流体成分、铁流体体积、解吸溶剂类型和体积、pH 值和萃取时间，以研究它们对氟沙星回收率的影响。在最佳条件下，氧氟沙星的线性范围为 1-10 mg L-1，相关系数为 0.9963。最低检出限和最低检测限分别为 0.75 和 1.55 µg L-1。日内和日间的 RSD%分别为 2.64 和 7.40。牛奶和鸡蛋样品的回收率为 80.8% 至 92.0%。根据所获得的结果，所开发的 MGO-DES FF LPME 方法在提取食品样品中的氧氟沙星时表现出了极高的灵敏度和效率。作为一种替代方法，它在萃取具有挑战性的基质中的药物活性污染物方面显示出巨大的潜力。

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来源期刊

Food Analytical Methods 农林科学-食品科技

CiteScore

6.00

自引率

3.40%

发文量

244

审稿时长

3.1 months

期刊介绍： Food Analytical Methods publishes original articles, review articles, and notes on novel and/or state-of-the-art analytical methods or issues to be solved, as well as significant improvements or interesting applications to existing methods. These include analytical technology and methodology for food microbial contaminants, food chemistry and toxicology, food quality, food authenticity and food traceability. The journal covers fundamental and specific aspects of the development, optimization, and practical implementation in routine laboratories, and validation of food analytical methods for the monitoring of food safety and quality.