The skin sensitization adverse outcome pathway: exploring the role of mechanistic understanding for higher tier risk assessment

IF 5.7 2区医学 Q1 TOXICOLOGY

Critical Reviews in Toxicology Pub Date : 2024-02-22 DOI:10.1080/10408444.2024.2308816

Maja Aleksic, Ramya Rajagopal, Renato de-Ávila, Sandrine Spriggs, Nicola Gilmour

引用次数: 0

Abstract

For over a decade, the skin sensitization Adverse Outcome Pathway (AOP) has served as a useful framework for development of novel in chemico and in vitro assays for use in skin sensitization hazard...

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皮肤过敏不良后果途径：探索机理认识对更高层次风险评估的作用

十多年来，皮肤过敏不良后果途径（AOP）一直是开发用于皮肤过敏危害的新型化学和体外检测方法的有用框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Critical Reviews in Toxicology 医学-毒理学

CiteScore

9.50

自引率

1.70%

发文量

期刊介绍： Critical Reviews in Toxicology provides up-to-date, objective analyses of topics related to the mechanisms of action, responses, and assessment of health risks due to toxicant exposure. The journal publishes critical, comprehensive reviews of research findings in toxicology and the application of toxicological information in assessing human health hazards and risks. Toxicants of concern include commodity and specialty chemicals such as formaldehyde, acrylonitrile, and pesticides; pharmaceutical agents of all types; consumer products such as macronutrients and food additives; environmental agents such as ambient ozone; and occupational exposures such as asbestos and benzene.