Evaluation of Serum LECT2 and Sclerostin Levels in Patients Followed up for Obstructive Sleep Apnea

IF 0.6 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry Pub Date : 2024-02-20 DOI:10.1134/S1990750823600425

Buğra Kerget, Gizem Çil, Dursun Erol Afşin, Alperen Aksakal, Esra Laloglu

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Abstract

Background: Obstructive sleep apnea (OSA) is characterized by recurrent apnea/hypopnea in the upper airways and oxygen desaturation accompanying respiratory events during sleep. Our study aimed to determine serum LECT2 and sclerostin levels in OSA patients. Methods: Patients who applied with the suspicion of OSA in the polysomnography unit of our hospital between June 2022 and April 2023 and who completed the polysomnography test were included in our study. Group 1: apnea-hypopnea index (AHI) < 5/h control group (n = 80), Group 2: OSA patients with AHI ≥ 5/h without comorbidity (n = 80). Results: When comparing the LECT2 and sclerostin levels of the groups, it was observed that there was a statistically significant difference, higher in the OSA group (p < 0.001 for both). When the groups were compared, it was observed that only LECT2 and sclerostin levels were higher in severe OSA patients than in mild OSA patients (p = 0.008, 0.02, respectively). A positive correlation was observed between LECT-2 level and AHI, apnea–hypopnea index during rapid eye movement (REM-AHI), and ODI levels (r = 0.55, p = 0.01, r = 0.42, p = 0.01, r = 0.61, p = 0.01). An inverse correlation was observed between LECT2 and minimum oxygen saturation (r = –0.42, p = 0.01). In the analysis performed with sclerostin level, a positive correlation (r = 0.42, p = 0.01, r = 0.28, p = 0.05, r = 0.53, p = 0.01) was observed with AHI, REM-AHI, and ODI, while an inverse correlation was observed between minimum oxygen saturation. Correlation was observed (r = –0.33, p = 0.01). Conclusion: Serum LECT2 and sclerostin levels in OSA patients can be used to determine the AHI and minimum oxygen saturation levels of individuals and their weight in OSA patients.

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评估阻塞性睡眠呼吸暂停随访患者的血清 LECT2 和硬骨蛋白水平

摘要背景：阻塞性睡眠呼吸暂停（OSA）的特征是上呼吸道反复出现呼吸暂停/低通气，以及睡眠期间伴随呼吸事件的氧饱和度降低。我们的研究旨在确定 OSA 患者的血清 LECT2 和硬骨蛋白水平。研究方法将 2022 年 6 月至 2023 年 4 月期间在我院多导睡眠监测室申请并完成多导睡眠监测的疑似 OSA 患者纳入研究。第一组：呼吸暂停-低通气指数（AHI）< 5/h对照组（n = 80），第二组：呼吸暂停-低通气指数（AHI）< 5/h对照组（n = 80）：AHI≥5/h且无合并症的 OSA 患者（n = 80）。结果：比较各组的 LECT2 和硬骨蛋白水平，发现 OSA 组的 LECT2 和硬骨蛋白水平较高，差异有统计学意义（均为 p <0.001）。对各组进行比较后发现，只有重度 OSA 患者的 LECT2 和硬骨蛋白水平高于轻度 OSA 患者（p = 0.008，0.02）。LECT-2水平与AHI、快速眼动时呼吸暂停-低通气指数（REM-AHI）和ODI水平之间呈正相关（r = 0.55，p = 0.01；r = 0.42，p = 0.01；r = 0.61，p = 0.01）。LECT2 与最低血氧饱和度之间呈负相关（r = -0.42，p = 0.01）。在对硬骨蛋白水平进行的分析中，观察到其与 AHI、REM-AHI 和 ODI 呈正相关（r = 0.42，p = 0.01；r = 0.28，p = 0.05；r = 0.53，p = 0.01），而与最低血氧饱和度呈反相关。观察到相关性（r = -0.33，p = 0.01）。结论OSA 患者的血清 LECT2 和硬骨蛋白水平可用于确定 OSA 患者的 AHI 和最低血氧饱和度水平及其体重。

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来源期刊

Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

1.10

自引率

0.00%

发文量

期刊介绍： Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry covers all major aspects of biomedical chemistry and related areas, including proteomics and molecular biology of (patho)physiological processes, biochemistry, neurochemistry, immunochemistry and clinical chemistry, bioinformatics, gene therapy, drug design and delivery, biochemical pharmacology, introduction and advertisement of new (biochemical) methods into experimental and clinical medicine. The journal also publishes review articles. All issues of the journal usually contain solicited reviews.